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个人简介
Research Interests
-influenza virus
-SARS-CoV-2
-antibodies
-antigenic drift
Key words: Influenza virus, SARS-CoV-2, antigenic drift, viral pathogenesis, viral receptors, antibody specificity, vaccines
Description of Research
Seasonal influenza viruses pose a major threat to the human population, contributing to over 30,000 annual deaths in the United States alone. Influenza viruses rapidly escape pre-existing humoral immunity by accumulating mutations in the viral surface proteins hemagglutinin (HA) and neuraminidase (NA). This process, termed “antigenic drift”, creates antigenically distinct viruses, making it difficult to predict which types of viruses will predominate during any given flu season. Antigenic drift is a problem for vaccine manufacturers.
The Hensley laboratory has 3 major scientific focuses related to influenza viruses: 1) elucidating mechanisms that promote antigenic drift of influenza viruses, 2) identifying factors that influence influenza vaccine responsiveness, 3) developing new influenza vaccine platforms. Our overarching goals are to use basic immunological and virological approaches to improve the process by which influenza vaccine strains are chosen, and to develop new influenza vaccines that are protective against antigenically diverse influenza strains.
In response to the COVID-19 pandemic, the Hensley laboratory is completing serological assays to identify individuals infected with SARS-CoV-2. Additional experiments are being completed to measure the durability and functionality of antibody responses elicited by SARS-CoV-2 in different individuals.
It is an exciting time to study viral immunology, and enthusiastic undergraduate, graduate, and postdoctoral fellows should email hensley@pennmedicine.upenn.edu if you are interested in joining the lab.
Lab members:
Claudia Arevalo (PhD student/IGG)
Marcus Bolton (PhD student/MVP)
Eileen Goodwin (PhD student/IGG)
Sigrid Gouma (postdoc)
Liz Anderson (postdoc)
Elizabeth Troisi (postdoc)
Nicole Tanenbaum (undergraduate)
Theresa Eilola (Research assistant)
Madison Weirick (Research assistant)
Christopher McAllister (Research assistant
-influenza virus
-SARS-CoV-2
-antibodies
-antigenic drift
Key words: Influenza virus, SARS-CoV-2, antigenic drift, viral pathogenesis, viral receptors, antibody specificity, vaccines
Description of Research
Seasonal influenza viruses pose a major threat to the human population, contributing to over 30,000 annual deaths in the United States alone. Influenza viruses rapidly escape pre-existing humoral immunity by accumulating mutations in the viral surface proteins hemagglutinin (HA) and neuraminidase (NA). This process, termed “antigenic drift”, creates antigenically distinct viruses, making it difficult to predict which types of viruses will predominate during any given flu season. Antigenic drift is a problem for vaccine manufacturers.
The Hensley laboratory has 3 major scientific focuses related to influenza viruses: 1) elucidating mechanisms that promote antigenic drift of influenza viruses, 2) identifying factors that influence influenza vaccine responsiveness, 3) developing new influenza vaccine platforms. Our overarching goals are to use basic immunological and virological approaches to improve the process by which influenza vaccine strains are chosen, and to develop new influenza vaccines that are protective against antigenically diverse influenza strains.
In response to the COVID-19 pandemic, the Hensley laboratory is completing serological assays to identify individuals infected with SARS-CoV-2. Additional experiments are being completed to measure the durability and functionality of antibody responses elicited by SARS-CoV-2 in different individuals.
It is an exciting time to study viral immunology, and enthusiastic undergraduate, graduate, and postdoctoral fellows should email hensley@pennmedicine.upenn.edu if you are interested in joining the lab.
Lab members:
Claudia Arevalo (PhD student/IGG)
Marcus Bolton (PhD student/MVP)
Eileen Goodwin (PhD student/IGG)
Sigrid Gouma (postdoc)
Liz Anderson (postdoc)
Elizabeth Troisi (postdoc)
Nicole Tanenbaum (undergraduate)
Theresa Eilola (Research assistant)
Madison Weirick (Research assistant)
Christopher McAllister (Research assistant
研究兴趣
论文共 146 篇作者统计合作学者相似作者
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Timothy S. Johnston, Shuk Hang Li,Mark M. Painter, Reilly K. Atkinson, Naomi R. Douek,David B. Reeg,Daniel C. Douek,E. John Wherry,Scott E. Hensley
Immunityno. 4 (2024): 912-925.e4
medRxiv : the preprint server for health sciences (2024)
bioRxiv : the preprint server for biology (2024)
Elise A Chong,Kingsley Gideon Kumashie,Emeline R Chong, Joseph Fabrizio,Aditi Gupta,Jakub Svoboda,Stefan K Barta,Kristy M Walsh,Ellen B Napier, Rachel K Lundberg,Sunita D Nasta,James N Gerson,
The Journal of infectious diseases (2024)
Alan Randall Anderson,John J. Strouse,Deepa Manwani,Amanda M. Brandow,Elliott P. Vichinsky, Patrick Leavey,Joshua Field,Scott Hensley, Nicole Mortier,Sophie M. Lanzkron,Donna S. Neuberg,Charles S. Abrams
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv : the preprint server for biology (2023)
Marcus J. Bolton,Jefferson J. S. Santos,Claudia P. Arevalo,Trevor Griesman, Megan Watson, Shuk Hang Li,Paul Bates,Holly Ramage,Patrick C. Wilson,Scott E. Hensley
JOURNAL OF VIROLOGYno. 1 (2023): e0172322-e0172322
Mark M Painter,Timothy S Johnston,Kendall A Lundgreen,Jefferson J S Santos,Juliana S Qin,Rishi R Goel,Sokratis A Apostolidis,Divij Mathew, Bria Fulmer,Justine C Williams, Michelle L McKeague,Ajinkya Pattekar,
biorxiv(2023)
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