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The major focus of research in my laboratory is centered on bacterial pathogenesis of Yersinia enterocolitica and Y. pestis, etiologic agents of yersiniosis and bubonic plague respectively. The hallmark of these infectious agents is their ability to suppress the innate immune response of mammalian hosts. This is accomplished actively by injecting protein anti-host factors directly into white blood cells to circumvent cytokine induction, and passively by repressing or modifying bacterial surface components recognized by toll-like receptors (TLRs). Deacylation of lipidA reduces activation of TLR-4. Transcriptional arrest (Y. enterocolitica) or permanent mutational silencing of flagellin (Y. pestis) circumvents activation of host cell TLR-5. Flagellin, the major filament protein of the bacterial flagellin is exported to the cell surface via a type III protein secretion system (TTSS), the same type of export mechanism used to deliver virulence proteins to macrophages.
The major focus of research in my laboratory is centered on bacterial pathogenesis of Yersinia enterocolitica and Y. pestis, etiologic agents of yersiniosis and bubonic plague respectively. The hallmark of these infectious agents is their ability to suppress the innate immune response of mammalian hosts. This is accomplished actively by injecting protein anti-host factors directly into white blood cells to circumvent cytokine induction, and passively by repressing or modifying bacterial surface components recognized by toll-like receptors (TLRs). Deacylation of lipidA reduces activation of TLR-4. Transcriptional arrest (Y. enterocolitica) or permanent mutational silencing of flagellin (Y. pestis) circumvents activation of host cell TLR-5. Flagellin, the major filament protein of the bacterial flagellin is exported to the cell surface via a type III protein secretion system (TTSS), the same type of export mechanism used to deliver virulence proteins to macrophages.
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Scientific Reportsno. 1 (2023): 9874-9874
Applied and Environmental Microbiologyno. 2 (2023)
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Kimberly R. Andrews,Daniel D. New, Digpal S. Gour, Kane Francetich,Scott A. Minnich, Barrie D. Robison,Carolyn J. Hovde
SCIENTIFIC REPORTSno. 1 (2023)
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