My research focuses on the diagnosis, pathogenesis and prognosis of breast cancer. I am interested in finding newer and better modalities for the diagnosis of breast cancer. I would also like to better understand how a normal breast ductal epithelial cell becomes malignant. Along with many researchers, we are looking at normal and atypical duct cells grown in 3D culture to elucidate the initial steps in carcinogenesis, and we are dissecting the molecular mechanisms of breast cancer progression to identify markers in the blood that can predict the presence of a breast cancer. In addition, by using gene arrays we are trying to identify gene signatures that predict better response to chemotherapy and can identify patients with aggressive tumors despite favorable pathologies.