During this time Prof Edwards developed a strong research theme investigating links between ageing and longevity mechanisms and the onset of musculoskeletal disease, with work recognised with ASBMR, ECTS and IBMS awards. This ongoing work forms the basis of the Oxford Skeletal Ageing and Regeneration group, which aims to understand the causes of age-related skeletal decline and better address the consequences of such disorders. In recent years, this has included the study of sirtuin biology in musculoskeletal tissues and how the acetylation status of key intracellular proteins fine tunes normal cell biology and function with increasing age, how the cellular recycling process of autophagy declines in ageing cartilage and can be activated to protect against arthritis disease, and how novel degradable alloys can improve fracture healing and bone repair.