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Understanding the molecular and cellular mechanisms regulating the development, patterning and postnatal renewal of the skin and ectodermal appendage organs such as hair follicles, teeth, and taste papillae, and identifying stem and progenitor cell populations in these organs, is critical for developing new therapies to accelerate wound healing, treat hair loss diseases, repair or replace diseased teeth, and ameliorate taste dysfunction. Research in the Millar lab focuses on cell-cell signaling and epigenetic mechanisms that underlie these processes. In published research, we identified Wnt/beta-catenin signaling as a key pathway required for initiating the formation of ectodermal appendages from multipotent cells in mammalian embryos, and in controlling development and patterning of haired versus hairy skin.
Understanding the molecular and cellular mechanisms regulating the development, patterning and postnatal renewal of the skin and ectodermal appendage organs such as hair follicles, teeth, and taste papillae, and identifying stem and progenitor cell populations in these organs, is critical for developing new therapies to accelerate wound healing, treat hair loss diseases, repair or replace diseased teeth, and ameliorate taste dysfunction. Research in the Millar lab focuses on cell-cell signaling and epigenetic mechanisms that underlie these processes. In published research, we identified Wnt/beta-catenin signaling as a key pathway required for initiating the formation of ectodermal appendages from multipotent cells in mammalian embryos, and in controlling development and patterning of haired versus hairy skin.
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论文共 188 篇作者统计合作学者相似作者
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Yaqing Zhang, John P. Morris, Wei Yan, Heather K. Schofield,Austin Gurney,Diane M. Simeone,Sarah E. Millar,Timothy Hoey,Matthias Hebrok,Marina Pasca di Magliano
crossref(2023)
Yaqing Zhang, John P. Morris, Wei Yan, Heather K. Schofield, Austin Gurney,Diane M. Simeone,Sarah E. Millar, Timothy Hoey,Matthias Hebrok,Marina Pasca di Magliano
crossref(2023)
Yaqing Zhang, John P. Morris, Wei Yan, Heather K. Schofield,Austin Gurney,Diane M. Simeone,Sarah E. Millar,Timothy Hoey,Matthias Hebrok,Marina Pasca di Magliano
crossref(2023)
Journal of Investigative Dermatologyno. 5 (2023): S246-S246
crossref(2023)
Qi Sun,Wendy Lee,Hai Hu, Tatsuya Ogawa, Sophie De Leon, Ioanna Katehis,Chae Ho Lim,Makoto Takeo,Michael Cammer,M. Mark Taketo,Denise L. Gay,Sarah E. Millar,
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