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个人简介
The Mole lab is interested in disease caused by genetic changes, and how study of these mutations and their effects can reveal important and complex aspects of cell biology that may otherwise be beyond current appreciation.
We are particularly interested in neurodegenerative diseases. We focus on lysosomal disorders, especially the neuronal ceroid lipofuscinoses (NCLs) or Batten disease, which are inherited neurodegenerative diseases that start in childhood. We work along the full translational pathway, studying their genetics and biology, and are developing new and much-needed therapies. Our work will help to provide new therapeutic targets for all types of neurodegeneration.
We are particularly interested in neurodegenerative diseases. We focus on lysosomal disorders, especially the neuronal ceroid lipofuscinoses (NCLs) or Batten disease, which are inherited neurodegenerative diseases that start in childhood. We work along the full translational pathway, studying their genetics and biology, and are developing new and much-needed therapies. Our work will help to provide new therapeutic targets for all types of neurodegeneration.
研究兴趣
论文共 236 篇作者统计合作学者相似作者
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Marisa Ofrim,Daniel Little, Mina Nazari, Christopher J. Minnis,Michael J. Devine,Sara E. Mole,Paul Gissen,Maelle Lorvellec
STEM CELL RESEARCH (2024): 103291-103291
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Wenfei Liu,Amy Geard,Giulia Massaro,Michael Paul Hughes, Mikel Aristorena, Olha Semenyuk,Ryea Maswood,Alexander J. Smith,Robin R. Ali,Sara Mole,Ahad A. Rahim
MOLECULAR THERAPYno. 4 (2023): 465-466
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Journal of Biological Chemistryno. 5 (2023): 104649-104649
F1000Research (2022)
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biorxiv(2022)
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