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Studies from this laboratory identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies. Cell surface GRP78 functions as a signaling receptor promoting tumor proliferation and suppressing apoptosis. Patients with a number of malignancies mount an autoimmune response to GRP78 and these antibodies, which bind to the NH2 terminal domains of GRP78, are receptor agonists whose appearance is a marker of poor prognosis. More recently, we have shown that antibodies directed against the COOH-terminal domain of GRP78 are receptor antagonists which may have therapeutic potential for treating patients whose tumors express GRP78 on the cell surface.
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Mario Gonzalez-Gronow,Jenny L. Fiedler, Cristian Farias Gomez,Fang Wang,Rupa Ray, Paul D. Ferrell,Salvatore V. Pizzo
Biochemical and Biophysical Research Communicationsno. 3 (2017): 855-860
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathologyno. 3 (2016): 258-269
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