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The research team directed by Dr. Langer discovered between the years 1979-1980 a specific, high-affinity binding site labeled with for 3H-imipramine and later with 3H-paroxetine, which is associated with the serotonin transporter in the brain and in blood platelets of various species, including man. 3H-paroxetine binding was subsequently used as a marker in the purification of the serotonin transporter for cloning and expression.
Throughout the 80's Dr. Langer continued his work on presynaptic autoreceptors regulating NE, DA and 5-HT release and reported the interactions in neurotransmission between the neuronal transporter and the corresponding autoreceptor.
During the 23 years at Synthelabo, Dr. Langer discovered and developed five compounds : diltiazem, a calcium antagonist (for coronary insufficiency); betaxolol, a beta-1 adrenoceptor selective antagonist for hypertension and also for local use in the treatment of glaucoma; zolpidem , a selective full agonist of the alpha-1 subunit of the benzodiazepine-GABA-A receptor (for insomnia) and mizolastine, a peripherally acting histamine H-1 receptor antagonist which also inhibits the formation of leukotriens(for allergic diseases).
Throughout the 80's Dr. Langer continued his work on presynaptic autoreceptors regulating NE, DA and 5-HT release and reported the interactions in neurotransmission between the neuronal transporter and the corresponding autoreceptor.
During the 23 years at Synthelabo, Dr. Langer discovered and developed five compounds : diltiazem, a calcium antagonist (for coronary insufficiency); betaxolol, a beta-1 adrenoceptor selective antagonist for hypertension and also for local use in the treatment of glaucoma; zolpidem , a selective full agonist of the alpha-1 subunit of the benzodiazepine-GABA-A receptor (for insomnia) and mizolastine, a peripherally acting histamine H-1 receptor antagonist which also inhibits the formation of leukotriens(for allergic diseases).
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Jean‐Martin Beaulieu,Emiliana Borrelli,Arvid Carlsson,Marc G. Caron,Olivier Civelli,Stefano Espinoza, Gilberto Fisone,Raul R. Gainetdinov,David K. Grandy, John W. Kebabian,Saloman Z. Langer,Maria Cristina Missale,
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
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Jean-Martin Beaulieu,Emiliana Borrelli,Arvid Carlsson,Marc G. Caron,Olivier Civelli,Stefano Espinoza, Gilberto Fisone,Raul R. Gainetdinov,David K. Grandy, John W. Kebabian,Saloman Z. Langer,Maria Cristina Missale,
IUPHAR/BPS guide to pharmacology CITEno. 4 (2019)
BIOGENIC AMINES: PHARMACOLOGICAL, NEUROCHEMICAL AND MOLECULAR ASPECTS IN THE CNS (2010)
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JOURNAL OF PHYSIOLOGICAL SCIENCESno. SUPnan (2009): 107-107
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