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MicroRNAs and Viral Infections
Viruses have been demonstrated to alter the expression of human microRNAs, cause specific degradation of microRNAs, and even encode their own, virally-derived microRNAs. These can all aid in maintaining viral latency, evasion of immune responses, and ultimately can dictate the outcomes of viral infections. Conversely, human microRNAs can alter the immune system and directly regulate responses to viral infections. Numerous broadly antiviral microRNAs have now been identified; however, their targets and roles in viral infections remain mysterious. What are the target genes of these microRNAs? How do they influence the viral life cycle? What is their role in modulating the immune response and disease pathogenesis? Can they be targeted for antiviral therapy? The answers to these questions will provide a broader understanding of the role of microRNAs in viral infections, immune responses, and disease pathogenesis.
MicroRNAs and Viral Infections
Viruses have been demonstrated to alter the expression of human microRNAs, cause specific degradation of microRNAs, and even encode their own, virally-derived microRNAs. These can all aid in maintaining viral latency, evasion of immune responses, and ultimately can dictate the outcomes of viral infections. Conversely, human microRNAs can alter the immune system and directly regulate responses to viral infections. Numerous broadly antiviral microRNAs have now been identified; however, their targets and roles in viral infections remain mysterious. What are the target genes of these microRNAs? How do they influence the viral life cycle? What is their role in modulating the immune response and disease pathogenesis? Can they be targeted for antiviral therapy? The answers to these questions will provide a broader understanding of the role of microRNAs in viral infections, immune responses, and disease pathogenesis.
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The Journal of general virologyno. 1 (2024)
Elnaz Alebrahim,Hediyeh Khatibnezhad, Morvarid Mohammadian Bajgiran,Magan Solomon,Chen Liang,Selena M. Sagan,Rogerio S. Lima, Joerg Oberste Berghaus,Maniya Aghasibeig,Christian Moreau
CATALYSTSno. 7 (2023): 1141-1141
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The Journal of general virologyno. 6 (2023)
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