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Wray's early research focused on changes of connective tissue in the uterus during and after pregnancy. She then helped develop spectroscopic methods to characterize metabolism in human neonates. Since moving to Liverpool, she has focused on the relationship between metabolism and function in smooth muscle. In particular, she has elucidated the effects of pH on contractility. In order to elucidate the underlying mechanisms, she performed some of the first measurements of intracellular calcium in smooth muscle. Subsequent work into the relationship between calcium and excitability led to new understanding of the origin of the refractory period in the ureter. Her translational work has led to measurements of lactate to predict labour outcome and to the use of bicarbonate to increase the pH of the mother and thereby increase the strength of uterine contractions, reducing the requirement for caesarean sections. She has also shown that problems of labour experienced by obese mothers can be explained by impaired smooth muscle contractility.
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Physiology (Bethesda, Md.)no. 3 (2024): 0-0
Clodagh Prendergast,Susan Wray, Daniella Dungate, Christine Martin, Andra Vaida, Elizabeth Brook, Cecilia Ani Chioma,Helen Wallace
Current Research in Physiology (2024): 100122-100122
BMJ-BRITISH MEDICAL JOURNAL (2023): e076515-e076515
Sayah Ongsricharoenbhorn, Pakanit Kupittayanant,Kanjana Thumanu,Griangsak Eumkeb, Suthida Chanlun, Pittaya Papirom,Susan Wray,Sajeera Kupittayanant
Chinese Journal of Integrative Medicineno. 11 (2023): 980-988
PHYSIOLOGICAL REPORTSno. 23 (2023): n/a-n/a
Pauline Slade,Kayleigh Sheen,Andrew Weeks,Susan Wray,Leonardo De Pascalis, Karen Lunt,Carol Bedwell, Belinda Thompson,Johnathan Hill,Helen Sharp
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