基本信息
浏览量:0
职业迁徙
个人简介
Dr. Viswanathan’s research program is focused on developing novel cell based therapies for Osteoarthritis. Her research has dual foci: i) understanding inflammation and immune cell interactions that drive joint inflammation and cartilage degradation in osteoarthritis (OA), and ii) using advanced engineering/manufacturing solutions to develop more potent and stable anti-inflammatory cellular therapies for treating OA. One of the aims is focused on the role of monocytes/macrophages in joint inflammation and degradation, to identify molecular and cellular metabolic regulators of monocyte/macrophage dysregulation, which contributes to this pathology. This will improve our understanding of OA pathology and enable the development of monocyte/macrophage-based therapies.
Mesenchymal stromal cells (MSCs) with anti-inflammatory and immunomodulatory properties are emerging as promising symptom- and potentially disease-modifying treatments. Dr. Viswanathan has successfully driven the clinical translation of a first-in-Canada and made-in-Canada MSC trial in knee Osteoarthritis. Dr. Viswanathan is proposing to use engineering/manufacturing solutions to “boost” MSCs and improve their anti-inflammatory and immunomodulatory potential in the context of OA. She is evaluating these enhanced next-generation MSCs in OA explant and animal models prior to clinical trials.
Mesenchymal stromal cells (MSCs) with anti-inflammatory and immunomodulatory properties are emerging as promising symptom- and potentially disease-modifying treatments. Dr. Viswanathan has successfully driven the clinical translation of a first-in-Canada and made-in-Canada MSC trial in knee Osteoarthritis. Dr. Viswanathan is proposing to use engineering/manufacturing solutions to “boost” MSCs and improve their anti-inflammatory and immunomodulatory potential in the context of OA. She is evaluating these enhanced next-generation MSCs in OA explant and animal models prior to clinical trials.
研究兴趣
论文共 134 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Osteoarthritis and Cartilage (2024): S444
Osteoarthritis and Cartilage (2024): S422
Osteoarthritis and Cartilage (2024): S285
Osteoarthritis and Cartilage (2024): S109-S110
Osteoarthritis and Cartilage (2023): S317-S317
引用0浏览0引用
0
0
Osteoarthritis and Cartilage (2023): S57-S57
引用0浏览0引用
0
0
Cellular & molecular immunologyno. 6 (2023): 626-650
Osteoarthritis and Cartilage (2023): S322-S322
引用0浏览0引用
0
0
Osteoarthritis and Cartilage (2023): S325-S325
引用0浏览0引用
0
0
Sowmya Viswanathan,Katarina Le Blanc,Rachele Ciccocioppo, Georges Dagher,Anthony J Filiano,Jacques Galipeau,Mauro Krampera, Lena Krieger,Manoj M Lalu,Jan Nolta, Viviana Marcela Rodriguez Pardo,Yufang Shi,
Cytotherapyno. 8 (2023): 803-807
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn