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The early interactions between a pathogen (e.g. virus) and the immune system are of central importance for the eventual outcome – pathology and disease versus clearance and reestablishment of homeostasis. In my laboratory we are interested in understanding the early events that occur during immunological challenge, and to characterize the impact on the control of infections. The innate immune system utilizes pattern recognition receptors to sense infections and to induce antimicrobial responses. In the case of virus infections, the type I interferons are particularly well-described to have strong antiviral activity. However, type I interferon can also cause significant pathology, and there is increasing appreciation of antiviral activities, which are independent of type I interferon. We seek to understand the mechanisms involved in both interferon-dependent and –independent antiviral immunity, and the interactions between these activities. Since many immunological phenomena occurring during viral infections are also involved in the pathology of non-communicable diseases, e.g. autoinflammatory diseases, we are also interested in uncovering the immunological basis for a panel of human pathologies.
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论文共 91 篇作者统计合作学者相似作者
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Journal of Neuroimmunologypp.578342, (2024)
Demi van der Horst,Naziia Kurmasheva,Mikkel H. S. Marqvorsen,Sonia Assil, Anna H. F. Rahimic, Christoph F. Kollmann, Leandro Silva da Costa,Qi Wu, Jian Zhao, Eleonora Cesari,Marie B. Iversen,Fanghui Ren,
Research Square (Research Square)no. 1 (2024): 1-15
Bao-Cun Zhang, Marlene F Laursen, Lili Hu, Hossein Hazrati,Ryo Narita, Lea S Jensen,Aida S Hansen,Jinrong Huang,Yan Zhang, Xiangning Ding, Maimaitili Muyesier, Emil Nilsson,
Nature communicationsno. 1 (2024): 2760-2760
Ensieh Farahani,Line S. Reiner,Ryo Narita, Manutea C. Serrero,Morten Kelder Skouboe,Demi van der Horst, Soni Assil,Baocun Zhang,Marie B. Iversen,Eugenio Gutierrez, Hossein Hazrati,Mogens Johannsen,
CELL REPORTSno. 2 (2024): 113792-113792
Demi van der Horst,Naziia Kurmasheva,Mikkel H. S. Marqvorsen,Sonia Assil, Anna H. F. Rahimic, Christoph F. Kollmann, Leandro Silva da Costa,Qi Wu, Jian Zhao, Eleonora Cesari,Marie B. Iversen,Fanghui Ren,
Communications Biologyno. 1 (2024): 1-15
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Nature cell biologyno. 3 (2023): 379-380
Life science allianceno. 8 (2023): e202301997-e202301997
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Stefanie Fruhwürth,Line S Reinert, Carl Öberg,Marcelina Sakr, Marcus Henricsson,Henrik Zetterberg,Søren R Paludan
biorxiv(2023)
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