She is a National Health and Medical Research Council Leadership Fellow. Professor Middleton has led a 15 year program of stroke research evaluating how to implement evidence-based stroke care. She has obtained 115 grants totalling $109.3M. Professor Middleton is Director of the Maridulu Budyari Gumal, the Sydney Partnership for Health, Education, Research and Enterprise (SPERE) Nursing and Midwifery Implementation Science Academy. She is also Chair of the Steering Committee of the Australian Stroke Clinical Registry. She is a Fellow of the Australian Academy of Health and Medical Sciences. In November 2023, Professor Middleton was awarded the 2023 American Heart Association on Cardiovascular and Stroke Nursing (CVSN) Stroke Council ‘Stroke Article of the Year Award’ for leading the Quality in Acute Stroke Care (QASC) Europe study in 64 hospitals within 17 European countries. Additionally, in November 2023, Professor Sandy Middleton and the other Assessment and CommuniCation ExcelLEnce foR sAfe paTient outcomEs Plus (ACCELERATE Plus) investigators, won the ‘2023 Australian Clinical Trials Alliance Consumer Involvement Award’ for the ACCELERATE Plus Trial: a stepped-wedge cluster randomised controlled trial to assess the effect of improving patient assessment and clinical communication on patient adverse events. She also was a finalist in the Engagement Australia Excellence Awards 2022, for Outstanding Engagement for Research Impact for the QASC research program.