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个人简介
Dr. Kalams was the first to demonstrate the persistence of HIV-1 specific cytotoxic T lymphocyte (CTL) clones in vivo during chronic HIV infection, and has received NIH R01-funding to 1) Evaluate why CTL responses decline with disease progression, 2) Assess the T-cell repertoire of developing and established immune responses, and 3) Determine whether the avidity of developing CTL responses influences viral set point. Other research interests include understanding the mechanisms of immune escape from CTL recognition (to evaluate the role HIV sequence variation plays in disease progression), and the evaluation of CTL responses of patients with long-term non-progressing HIV-1 infection (to evaluate whether patients without disease progression have unique or more robust immune responses).
Current active projects include the development of mass cytometry as a platform for evaluation of T cell phenotype and function, and molecular analysis of pathogen-specific T cells. We have developed assays to sort individual T cells, followed by identification of their T cell receptor alpha beta chain usage as well as their transcriptional profile. This allows an in depth evaluation of T cell responses after either natural infection or vaccination.
Current active projects include the development of mass cytometry as a platform for evaluation of T cell phenotype and function, and molecular analysis of pathogen-specific T cells. We have developed assays to sort individual T cells, followed by identification of their T cell receptor alpha beta chain usage as well as their transcriptional profile. This allows an in depth evaluation of T cell responses after either natural infection or vaccination.
研究兴趣
论文共 234 篇作者统计合作学者相似作者
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EUROPEAN JOURNAL OF IMMUNOLOGYno. 1 (2024): e2350590-e2350590
EBioMedicine (2024): 104987
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Maurine D. Miner,Allan Decamp,Nicole Grunenberg,Stephen C. De Rosa,Andrew Fiore-Gartland, Katherine Bar,Paul Spearman,Mary Allen, Pei-Chun Yu,Bryce Manso,Nicole Frahm,Spyros Kalams,
EBIOMEDICINE (2024): 104987-104987
bioRxiv : the preprint server for biology (2024)
CLINICAL INFECTIOUS DISEASESno. 1 (2024): 217-226
Vaccineno. 16 (2023): 2696-2706
Magdalena E Sobieszczyk,Sharon Mannheimer, Carmen A Paez,Chenchen Yu, Theresa Gamble, Deborah A Theodore,Wairimu Chege, Margaret Yacovone,Brett Hanscom,Jack Heptinstall,Kelly E Seaton,Lily Zhang,
The lancet. HIVno. 10 (2023): e653-e662
Celestine N. Wanjalla, J. Aaron Simmons,Jared Oakes, Xiuqi Zhang, Cindy Nochowivz,Stephen Priest,Samuel Bailin, Christopher M Watten,Mona Mashayekhi,Heather K. Beasley,Jian Wang,Leslie M. Meenderink,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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The New England journal of medicineno. 4 (2023): 374-376
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