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The first research topic: pathogenesis and possible treatment of rheumatoid arthritis (RA)
For inflammatory mediators with pathogenicity, what are the effects of gene regulation in the manufacturing process of synovial fibroblast and bone cells, including signal transduction, transcriptional regulation, transcription factor / promoter interactions, or over expression, silencing, and mutation on the production of these mediators?
In vitro / in vivo correlation: to establish a disease model of collagen induced arthritis (CIA) in mice, and to detect the effects of these mediators that may inhibit or promote RA on the progress of CIA according to the results of "1"
a. Gene therapy: the gene of a specific medium or the small hairpin RNA (shRNA) of the gene was inserted into lentivirus, and then the filtered virus was injected into mice to do over expression or knock out of the gene
b. Recently, we have also cooperated with other laboratories to develop nano technology for packaging and transferring genes, hoping to improve the efficiency of gene therapy.
c. Work with other teams to develop transgenic mice for specific mediators.
In order to detect the progress of CIA in a, B and C, histopathology combined with image analysis, such as X-ray and computed tomography, will be used to analyze and detect the influence of these media on the progress of CIA, hoping to develop a possible new treatment strategy for RA from the above research.
The second research topic: we will also establish other common dental disease models, such as chronic apical periodonitis, diphosphonate related osteonecrosis of the jaw (BRONJ), and detect the expression of these mediators found in I-1.
For inflammatory mediators with pathogenicity, what are the effects of gene regulation in the manufacturing process of synovial fibroblast and bone cells, including signal transduction, transcriptional regulation, transcription factor / promoter interactions, or over expression, silencing, and mutation on the production of these mediators?
In vitro / in vivo correlation: to establish a disease model of collagen induced arthritis (CIA) in mice, and to detect the effects of these mediators that may inhibit or promote RA on the progress of CIA according to the results of "1"
a. Gene therapy: the gene of a specific medium or the small hairpin RNA (shRNA) of the gene was inserted into lentivirus, and then the filtered virus was injected into mice to do over expression or knock out of the gene
b. Recently, we have also cooperated with other laboratories to develop nano technology for packaging and transferring genes, hoping to improve the efficiency of gene therapy.
c. Work with other teams to develop transgenic mice for specific mediators.
In order to detect the progress of CIA in a, B and C, histopathology combined with image analysis, such as X-ray and computed tomography, will be used to analyze and detect the influence of these media on the progress of CIA, hoping to develop a possible new treatment strategy for RA from the above research.
The second research topic: we will also establish other common dental disease models, such as chronic apical periodonitis, diphosphonate related osteonecrosis of the jaw (BRONJ), and detect the expression of these mediators found in I-1.
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Wei-Chun Chuang,Cheng-Ning Yang,Han-Wei Wang,Sze-Kwan Lin, Ching-Chu Yu, Jhe-Hao Syu,Chun-Pin Chiang,Young-Ji Shiao,Yi-Wen Chen
Journal of Dental Sciences (2024)
Journal of endodonticsno. 9 (2023): 1129-1137
Journal of bone and mineral metabolismno. 6 (2023): 772-784
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