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The Bensinger laboratory is focused on understanding how lipid metabolism influences the growth, survival and function of rapidly dividing normal and neoplastic cells. His laboratory recently revealed a lipid metabolic checkpoint that regulates cell cycle progression, cellular growth and viability in lymphocytes. Key ongoing studies include elucidating the signal transduction and regulatory networks that link growth receptor signaling to lipid anabolic programs in the adaptive immune system. We are also interested in understanding how lipid signals influence adaptive immune responses and self-tolerance. Current studies in the laboratory have found that dysregulation of lipid metabolism intrinsically influences adaptive immune cell function and autoimmune pathogenesis. Other important studies in the laboratory are focused on determining if lipid metabolic programs contribute to carcinogenesis, tumor growth and pathogenesis. Finally, we continue to seek out how to target key aspects of lipid metabolism to decrease tumor growth and alter immune cell function.
The Bensinger laboratory is focused on understanding how lipid metabolism influences the growth, survival and function of rapidly dividing normal and neoplastic cells. His laboratory recently revealed a lipid metabolic checkpoint that regulates cell cycle progression, cellular growth and viability in lymphocytes. Key ongoing studies include elucidating the signal transduction and regulatory networks that link growth receptor signaling to lipid anabolic programs in the adaptive immune system. We are also interested in understanding how lipid signals influence adaptive immune responses and self-tolerance. Current studies in the laboratory have found that dysregulation of lipid metabolism intrinsically influences adaptive immune cell function and autoimmune pathogenesis. Other important studies in the laboratory are focused on determining if lipid metabolic programs contribute to carcinogenesis, tumor growth and pathogenesis. Finally, we continue to seek out how to target key aspects of lipid metabolism to decrease tumor growth and alter immune cell function.
研究兴趣
论文共 104 篇作者统计合作学者相似作者
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Andrea B Ball,Anthony E Jones, Kaitlyn B Nguyen, Amy Rios, Nico Marx, Wei Yuan Hsieh,Krista Yang,Brandon R Desousa,Kristen K.O. Kim,Michaela Veliova, Zena M del Mundo,Orian S. Shirihai,
biorxiv(2024)
Yajing Gao,John P Kennelly,Xu Xiao,Emily Whang,Alessandra Ferrari, Alexander H Bedard,Julia J Mack, Alexander H Nguyen,Thomas Weston, Lauren F Uchiyama, Min Sub Lee,Stephen G Young,
bioRxiv : the preprint server for biology (2024)
Natureno. 8004 (2024): 628-635
EMBO reportsno. 10 (2023)
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Katharina M Eyme,Alessandro Sammarco,Roshani Jha,Hayk Mnatsakanyan,Caline Pechdimaljian,Litia Carvalho,Rudolph Neustadt, Charlotte Moses, Ahmad Alnasser,Daniel F Tardiff,Baolong Su,Kevin J Williams,
bioRxiv : the preprint server for biology (2023)
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Journal of Immunologyno. 1 (2023): 73.07-73.07
Science Advancesno. 33 (2023)
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Neuro-oncologyno. Supplement_5 (2023): v275-v275
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