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个人简介
Our interests focus primarily upon enzymes that catalyse glycoside formation and hydrolysis, since these play crucial roles in all areas of biology. Applications of our research (see below) range from the development of new catalysts for industrial processes to the design, synthesis and testing of new therapeutics.
Understanding: Mechanistic studies are the foundation of our program and range from the discovery and analysis of “new” mechanisms by which enzymes catalyse these reactions through to development of a deeper understanding of how the enzymes for which we know the fundamental mechanisms achieve such enormous (107 fold) rate accelerations. The approaches adopted involve a combination of synthetic organic chemistry (synthesis of substrate analogues, inhibitors, etc.), molecular biology (cloning, mutagenesis, etc.,) and biochemistry (enzyme purification, kinetics, labeling, peptide mapping). These are often coupled with collaborative crystallographic and NMR studies of protein/ligand complexes to gain insights into structures, dynamics and electrostatics of the species along the enzyme’s reaction coordinates. We also utilise mass spectrometry for peptide mapping and gas phase studies. Central to our mechanistic studies are the databases CAZY and CAZYPEDIA.
研究兴趣
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The Journal of Heart and Lung Transplantationno. 4 (2023): S323-S323
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Jacob F. Wardman,Lyann Sim, Jennifer Liu, Teresa A. Howard,Andreas Geissner,Phillip M. Danby,Alisdair B. Boraston,Warren W. Wakarchuk,Stephen G. Withers
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Blood transfusion = Trasfusione del sangueno. 2 (2023): 106-110
GLYCOBIOLOGYno. 11 (2023): 1062-1062
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