基本信息
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职业迁徙
个人简介
Keywords
MR biophysics, Neuroimaging, Systems neuroscience
Introduction
Magnetic resonance imaging (MRI) is a very powerful non-invasive tool to visualize brain morphology, physiology, function and connectivity. However, MRI originates from water protons, thus its biological source is not straightforward. Especially, widely-used blood oxygenation-level dependent (BOLD) fMRI relies on the presumably close relationship between neural activity and hemodynamic responses. Therefore, it is crucial to understand underlying basis of fMRI for proper quantification and determining ultimate limits. Also MRI can image entire brain repeatedly from anesthetized to awake animals, and its readout can be combined with diverse manipulations such as sensory, electrical, chemical and optogenetic stimulation, and pharmacological interventions for answering system-level neural circuits. To obtain multimodal functional neuroimaging data, animal MRI facility (9.4 T and 15.2 T Bruker) is accompanied with a neurophysiology laboratory with electrophysiology, intrinsic optical imager, laser Doppler flowmeter, etc. Our research lab consisting of MR scientists and system neuroscientists focuses on three inter-related research themes; a) the development of physiological and functional MRI techniques, b) the investigation of biophysical and physiological sources of MRI signals (functional MRI, perfusion, diffusion, chemical exchange MRI), and c) the application of neuroimaging techniques to systems neuroscience research.
研究兴趣
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Mijin Kim,Keonmok Kim,Changyeop Jeon,Seonggi Kim,Bo-Yeon Lee, Min -Woo Lee,Taehyeong Jeon, Jaeyeon Choi, Hyeji Kim,Hyuneui Lim, Byungwha Lim,Sungwon Lee,
APPLIED MATERIALS TODAY (2024): 102076
Scientific Reportsno. 1 (2024): 1-12
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Science advancesno. 13 (2024): eadl0999-eadl0999
IBRO Neuroscience Reports (2023): S728-S728
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iScienceno. 5 (2023): 106655-106655
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IBRO Neuroscience Reports (2023): S281-S281
Proceedings of the National Academy of Sciences of the United States of Americano. 18 (2023)
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