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We study leukaemogenesis, with a particular focus on MYC, a potent oncoprotein, and the BCL-2 family of proteins, which control cell life and death. We pioneered transgenic models of human Burkitt’s lymphoma, which is provoked by MYC, and follicular lymphoma, provoked by BCL-2.
We collaborated in the development of agents called BH3 mimetics, which block the action of specific pro-survival Bcl-2 family proteins. Using our models, we have shown that a combination of a BH3 mimetic with low dose chemotherapy is highly efficacious in vivo against aggressive lymphomas that express high levels of BCL-2 and MYC. We are now testing BH3 mimetic combination therapy to treat acute myeloid leukaemia (AML).
We are currently investigating the role of MNT, a MYC-related protein, in lymphocytes and lymphoid tumours.
We collaborated in the development of agents called BH3 mimetics, which block the action of specific pro-survival Bcl-2 family proteins. Using our models, we have shown that a combination of a BH3 mimetic with low dose chemotherapy is highly efficacious in vivo against aggressive lymphomas that express high levels of BCL-2 and MYC. We are now testing BH3 mimetic combination therapy to treat acute myeloid leukaemia (AML).
We are currently investigating the role of MNT, a MYC-related protein, in lymphocytes and lymphoid tumours.
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论文共 194 篇作者统计合作学者相似作者
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Nicole D Vincelette,Xiaoqing Yu,Andrew T Kuykendall,Jungwon Moon, Siyuan Su,Chia-Ho Cheng, Rinzine Sammut, Tiffany N Razabdouski,Hai Vu Nguyen,Erika A Eksioglu,Onyee Chan,Najla Al Ali,
biorxiv(2023)
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Research Square (Research Square) (2022)
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