基本信息
浏览量:3
职业迁徙
个人简介
The hippocampal formation functions as a three-dimensional network. We have been developing MRI approaches that allow us to investigate the hippocampus as a circuit in humans and, most recently, in mice to understand how the hippocampus functions during normal associative memory, and how the hippocampus fails during aging and Alzheimer's disease.
We have focused on the longitudinal axis of the hippocampus in our studies of normal memory where we have human subjects process auditory and visual stimuli, in isolation or paired in time. Results from these studies suggest specific circuit mechanisms for how the hippocampus encodes and combines information during associative memory. We are currently extending this area of investigation into mice, which will allow us to uncover potential cellular and molecular mechanisms that underlie these circuit mechanisms. We have focused on the transverse axis of the hippocampal formation in our efforts to understand how the hippocampus fails in aging and Alzheimer's disease. Toward this goal, we have developed novel imaging approaches that measure hippocampal function with microscopic resolution.
We have focused on the longitudinal axis of the hippocampus in our studies of normal memory where we have human subjects process auditory and visual stimuli, in isolation or paired in time. Results from these studies suggest specific circuit mechanisms for how the hippocampus encodes and combines information during associative memory. We are currently extending this area of investigation into mice, which will allow us to uncover potential cellular and molecular mechanisms that underlie these circuit mechanisms. We have focused on the transverse axis of the hippocampal formation in our efforts to understand how the hippocampus fails in aging and Alzheimer's disease. Toward this goal, we have developed novel imaging approaches that measure hippocampal function with microscopic resolution.
研究兴趣
论文共 280 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCESno. 1899 (2024): 20220376-20220376
David J. J. Ma,Yanting Yang, Natalia Harguindeguy,Ye Tian,Scott A. Small, Feng Liu,Douglas L. Rothman,Jia Guo
JOURNAL OF MAGNETIC RESONANCE IMAGINGno. 3 (2024): 964-975
Philosophical transactions of the Royal Society of London. Series B, Biological sciencesno. 1899 (2024): 20220372-20220372
Proceedings of the National Academy of Sciences of the United States of Americano. 23 (2023)
medRxiv (Cold Spring Harbor Laboratory) (2023)
引用2浏览0引用
2
0
Nature Cell Biologyno. 10 (2023): 1-4
arxiv(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn