基本信息
浏览量:271
职业迁徙
个人简介
I have extensive experience in the development and preclinical testing of engineered cell therapies and signal transduction inhibitors in leukemia, in pediatric trials using both, and in the manufacture and use of cellular therapeutics in preclinical, GMP, and clinical trial settings. I currently lead/have led most of the CTL019 (CD19 CAR) clinical trials at CHOP, in the US, and globally. Our group at CHOP and U Penn has led the field of highly active CAR T cell therapy, culminating in the FDA approval of CTL019/tisagenlecleucel as Kymriah, the first CAR T product ever approved, and the first gene therapy approved in the US. Over the last 10 years, our team has built a one of the most capable cell therapy groups in the world at both CHOP and U Penn, which can implement cell therapy trials with GMP cell manufacturing (Penn CVPF), at registrational level, with full regulatory support, and unmatched clinical implementation. Our work now encompasses engineered cell therapies for non-malignant diseases, including sickle cell disease. I am committed to improving outcomes for children who undergo cell therapies including malignant and non-malignant engineered cell therapies and hematopoietic cell transplantation. The goal - changing the standard of care.
研究兴趣
论文共 653 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Alexander E. Doan,Katherine P. Mueller, Andy Y. Chen, Geoffrey T. Rouin,Yingshi Chen,Bence Daniel,John Lattin, Martina Markovska, Brett Mozarsky, Jose Arias-Umana,Robert Hapke,In-Young Jung,
NATURE (2024)
Caitlin W. Elgarten, Stephanie Heidemann,Jason L. Freedman,Stephan A. Grupp, Patricia Hankins,Stephan Kadauke,Yimei Li, Barbara McGlynn,Timothy S. Olson,Yongping Wang,Lisa Wray,Lei Wang,
Transplantation and Cellular Therapyno. 2 (2024): S9-S10
Leyuan Ma, Ranjani Ramasubramanian,Naveen K Mehta,Benjamin Cossette,Duncan M Morgan, Ina Sukaj,Elisa Bergaggio,Stephan Kadauke,Regina M Myers,Luca Paruzzo,Guido Ghilardi, Tomasz M Grzywa,
bioRxiv : the preprint server for biology (2024)
Transplantation and Cellular Therapyno. 2 (2024): S236
Transplantation and Cellular Therapyno. 2 (2024): S52-S53
Alexander Doan, Katherine Mueller, Andy Chen, Geoffrey Rouin, Yingshi Chen,Bence Daniel,John Lattin, Martina Markovska, Brett Mozarsky, Jose Arias-Umana,Robert Hapke,In-Young Jung,
Nikolaos Spyrou,Yu Akahoshi,Steven Kowalyk,George Morales, Rahnuma Beheshti, Paibel Aguayo-Hiraldo,Monzr M. Al Malki,Francis Ayuk,Peter Bader, Janna Baez,Alexandra Capellini,Hannah Choe,
Transplantation and Cellular Therapyno. Supplement 1 (2024): 779-779
Rebecca A. Gardner,Claire White, Magdi Elsallab, Stephanie Farnia, Ellen Fraint,Bambi Grilley,Alison Bateman-House,Stephan A. Grupp,Saad Kenderian,Frederick L. Locke,Sarah Nikiforow,Olalekan O. Oluwole,
Transplantation and Cellular Therapy (2024)
Nora M. Gibson,Caitlin W. Elgarten,Joseph H. Oved,Lisa Wray,Jason L. Freedman,Yongping Wang,Stephan Kadauke, Patricia Hankins,Peter Nicholas, Elizabeth Worster,Janet L. Kwiatkowski,Stephan A. Grupp,
Transplantation and Cellular Therapyno. 2 (2024): S301-S302
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn