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I have been involved in researching the genetic susceptibility to rheumatoid arthritis (RA) since I joined the Arthritis Research Centre of Excellence, based at the University of Manchester, UK in 1996. Initially focussing on linkage studies using the large collection of family samples collected at the Centre as part of the National Repository, I quickly moved onto genome wide association studies (GWAS), as part of the Wellcome Trust Case Control Consortium (WTCCC), before leading on the fine-mapping of RA loci in the Immunochip study (Nature Genetics, 2012). This study used over 27,000 samples and led to the discovery of 14 new RA susceptibility loci. In recent years my lab has focussed on understanding the mechanisms by which these DNA variants lead to an increase risk of disease. In collaboration with Peter Fraser (Babraham, Cambridge) and Chris Wallace (University of Cambridge), my group has developed methods to interrogate the regions that are associated with RA, mainly regulatory enhancer regions, to determine the interacting gene targets. Using this Capture HiC methodology we are discovering how long range interactions, often involving multiple regions associated with different autoimmune diseases, regulate gene expression. In addition I have established collaborations with Soumya Raychaudhuri (Harvard Medical School, Boston), Caroline Ospelt (Zurich) and David Sansom (UCL), to look at the immunological, epigenetic and non-coding RNA consequences of the RA associated regions. These methods include ChIP, ATAC-Seq, RNA-seq and CRISPR genome editing.
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论文共 256 篇作者统计合作学者相似作者
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Qiang Wang,Marta Martinez-Bonet,Taehyeung Kim, Jeffrey A. Sparks,Kazuyoshi Ishigaki,Xiaoting Chen,Marc Sudman,Vitor Aguiar, Sangwan Sim, Marcos Chinas Hernandez, Darren J. Chiu,Alexandra Wactor,
CELL GENOMICSno. 2 (2024)
The Journal of Allergy and Clinical Immunology (2023)
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Scientific reportsno. 1 (2023): 22796-22796
Chenfu Shi, Danyun Zhao,Stefano Rossi,Antonios Frantzeskos,James Ding,Carlo Ferrazzano, Charlotte Wynn, Ryan Hum, Ellie Richards, Muskan Gupta,Chuan Fu Yap,Darren Plant,
medRxiv (Cold Spring Harbor Laboratory) (2023)
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The Journal of allergy and clinical immunologyno. 5 (2023): 1237-1246
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Expert review of clinical pharmacologypp.1-10, (2023)
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Ali Al-Janabi,Steve Eyre,Amy C. Foulkes,Adnan R. Khan,Nick Dand,Ekaterina Burova, Bernadette DeSilva,Areti Makrygeorgou, Emily Davies,Catherine H. Smith,Christopher E.M. Griffiths,Andrew P. Morris,
EXPERT REVIEW OF CLINICAL PHARMACOLOGYno. 6 (2023): 549-558
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