基本信息
浏览量:37
职业迁徙
个人简介
ACADEMIC INTERESTS
The main research interest of our laboratory group is to examine the genetic control of autoimmune diseases to gain a better understanding of the mechanisms by which immune tolerance is broken. A major focus of our lab group is a human autoimmune syndrome called Autoimmune Polyglandular Syndrome Type 1 (APS1 or APECED), which is classically manifested by an autoimmune attack directed at multiple endocrine organs. This disease is inherited in a monogenic autosomal recessive fashion and the defective gene has been identified and is called Aire (for autoimmune regulator). Aire knockout mice, like their human counterparts, develop an autoimmune disease that is targeted to multiple organs. Through the use of the mouse model we, along with others, have determined that Aire plays an important role in immune tolerance by promoting the expression of many self proteins in specialized antigen presenting cells in the thymus called medullary epithelial cells (mTEC’s).
Recently, we have determined that this process is not only critical in the thymus, but also in peripheral lymphoid organs. Current studies in the lab are directed at further understanding the relative contribution of specialized Aire-expressing cells to immune tolerance in multiple autoimmune disease models. In addition to these ongoing studies, our laboratory is also interested the pathogenesis of autoimmune diabetes and in developing other models of autoimmune disease by using transgenic, knockout, and knock-in approaches.
The main research interest of our laboratory group is to examine the genetic control of autoimmune diseases to gain a better understanding of the mechanisms by which immune tolerance is broken. A major focus of our lab group is a human autoimmune syndrome called Autoimmune Polyglandular Syndrome Type 1 (APS1 or APECED), which is classically manifested by an autoimmune attack directed at multiple endocrine organs. This disease is inherited in a monogenic autosomal recessive fashion and the defective gene has been identified and is called Aire (for autoimmune regulator). Aire knockout mice, like their human counterparts, develop an autoimmune disease that is targeted to multiple organs. Through the use of the mouse model we, along with others, have determined that Aire plays an important role in immune tolerance by promoting the expression of many self proteins in specialized antigen presenting cells in the thymus called medullary epithelial cells (mTEC’s).
Recently, we have determined that this process is not only critical in the thymus, but also in peripheral lymphoid organs. Current studies in the lab are directed at further understanding the relative contribution of specialized Aire-expressing cells to immune tolerance in multiple autoimmune disease models. In addition to these ongoing studies, our laboratory is also interested the pathogenesis of autoimmune diabetes and in developing other models of autoimmune disease by using transgenic, knockout, and knock-in approaches.
研究兴趣
论文共 283 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Alessia Sticchi Damiani,Vera Holzmayer, Claudio Galli, Mariangela De Nuzzo,Mark Anderson,Gavin Cloherty,Nicola Di Renzo
Virusesno. 1 (2024): 71
bioRxiv : the preprint server for biology (2023)
Mark Anderson,Christine Spencer,Kevan Herold,Ashis Saha, Christian Hammer, Marshall Thompson, Samantha Liang,Zoe Quandt,Anastasia Lucas,Arabella Young
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
引用0浏览0引用
0
0
Kristen Lavelle,Chester E. Chamberlain,Mark S. Anderson,Michael German,Angel Nip,Stephen E. Gitelman
Journal of the Endocrine Societyno. Supplement_1 (2023)
引用0浏览0引用
0
0
HEPATOLOGY COMMUNICATIONSno. 4 (2023)
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (2023): 105532-105532
引用0浏览0WOS引用
0
0
Alicia Dunajcik, Kambria Haire,Jennifer D Thomas,Leah F Moriarty,Yuri Springer,Julie M Villanueva,Adam MacNeil,Benjamin Silk, Jeffrey B Nemhauser,Ramona Byrkit,Melanie Taylor,Krista Queen,
PLOS global public healthno. 3 (2023): e0001252-e0001252
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn