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The focus of my research program since 2000 has been on the development of a quantitative, high-throughput, mass-spectrometry-based lipid profiling technology and the application of this technology to identify alterations in lipid metabolism that occur as results of signaling events and/or stress responses. Through ongoing collaboration with researchers working in Arabidopsis, an organism that is particularly genetically tractable and relatively easy to grow and manipulate, we have been able to put into practice a very efficient lipid profiling technology. Funded by NSF, Kansas NSF EPSCoR, Kansas Technology Enterprise Corporation, Kansas Biomedical Infrastructure Network, and Kansas State, we have established the Kansas Lipidomics Research Center and its fee-for-service lipid profiling analytical laboratory at Kansas State, we have developed high-throughput, quantitative methods for all the major lipid polar classes in plants, yeast, and animals, and we have examined the role of lipids in physiological responses. The Lipidomics Center can also perform structural analysis and can analyze simple lipids and other metabolites.
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Bagyalakshmi Muthan,Jie Wang,Ruth Welti,Dylan K. Kosma,Linhui Yu, Bikash Deo, Subhiksha Khatiwada,Vijaya K.R. Vulavala,Kevin L. Childs,Changcheng Xu,Timothy P. Durrett, Sanju A. Sanjaya
Journal of Hazardous Materials (2024): 133951-133951
Metabolitesno. 4 (2023): 499-499
Mass Spectrometry for Lipidomicspp.601-624, (2023)
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