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My research is primarily aimed at a better understanding the etiology and pathology of Alzheimer’s disease (AD) by identifying risk-associated gene mutations/rare variants and using that information to delineate the molecular, cellular, and biochemical events leading to neurodegeneration and neuroinflammation in the brains of AD patients. A significant portion of AD is caused by the inheritance of defective genes; specific gene mutations increase or decrease lifetime risk for AD. To date, four different genes have been implicated to play a role in familial Alzheimer’s disease (FAD). My lab has been involved with the discovery of three of these genes, including the amyloid beta protein precursor [APP], presenilin 1 [PSEN1], and presenilin 2 [PSEN2], which harbor mutations that cause a rare “early-onset” form of the disease with virtually 100% certainty, usually under 60 years old. We have also devised human stem cell-derived mini-brain organoid models to determine the pathogenic mechanisms by which defects or variants carried by AD genes contribute to the neurodegenerative process. We are using these models for drug discovery efforts, with some already in or heading into clinical trials. I also direct the Alzheimer’s Genome Project, which has led to one of the world’s largest interactive databases of AD genetic and next-generation sequencing data. An in-depth understanding AD-associated gene mutations and rare variants lead to beta-amyloid deposition, neurodegeneration, neuroinflammation, and, ultimately, dementia will be invaluable for the development of novel treatments for AD.
研究兴趣
论文共 845 篇作者统计合作学者相似作者
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Annals of neurology (2024)
PloS oneno. 2 (2024): e0299972-e0299972
BRAIN BEHAVIOR & IMMUNITY-HEALTH (2024): 100743-100743
Georg Hahn,Dmitry Prokopenko, Julian Hecker,Sharon M Lutz,Kristina Mullin, Leinal Sejour,Winston Hide,Ioannis Vlachos, Stacia DeSantis,Rudolph E Tanzi,Christoph Lange
Briefings in bioinformaticsno. 4 (2024)
Sanghun Lee,Julian Hecker,Georg Hahn,Kristina Mullin,Alzheimer's Disease Neuroimaging Initiative (ADNI), Sharon M Lutz,Rudolph E Tanzi, Christoph Lange,Dmitry Prokopenko
Alzheimer's & dementia : the journal of the Alzheimer's Associationno. 5 (2024): 3397-3405
Piyali Saha,Ian Q. Weigle, Nicholas Slimmon, Pedro Blauth Poli,Priyam Patel,Xiaoqiong Zhang,Yajun Cao,Julia Michalkiewicz,Ashley Gomm,Can Zhang,Rudolph E. Tanzi,Nicholas Dylla,
Scientific Reportsno. 1 (2024): 1-17
Brain : a journal of neurology (2024)
Ping Bai,Frederick A. Bagdasarian,Yulong Xu, Yanli Wang, Yongle Wang,Ashley Gomm,Yanting Zhou,Rui Wu,Hsiao-Ying Wey,Rudolph E. Tanzi,Can Zhang,Yu Lan,
Journal of Medicinal Chemistry (2024)
ADVANCED SCIENCEno. 1 (2024): e2304545-e2304545
Dean Ornish, Catherine Madison,Miia Kivipelto,Colleen Kemp,Charles E. McCulloch,Douglas Galasko, Jon Artz,Dorene Rentz,Jue Lin, Kim Norman, Anne Ornish, Sarah Tranter,
Alzheimer's Research & Therapyno. 1 (2024): 1-17
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