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个人简介
Zhang is committed to finding a cure for epithelial ovarian cancer, the most lethal gynecological malignancy in the developed world. In addition, he investigates the aging process of normal mammalian cells and its role in both tissue aging and cancer development for the discovery of therapeutic applications.A major discovery in recent cancer genome-wide sequencing is the identification of significant genetic changes in chromatin-modifying genes. However, despite great strides in identifying the various epigenetic enzymes/factors involved in cancer, the translational application of these findings in cancer intervention remains to be explored. The Zhang lab will pursue these issues in the coming years by focusing on the epigenetic SWItch/Sucrose Non-Fermentable (SWI/SNF) and Polycomb repressive complex 2 (PRC2) complexes as proof of principles in the context of ovarian cancer.
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论文共 247 篇作者统计合作学者相似作者
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Cancer Researchno. 7_Supplement (2024)
Evgenii N. Tcyganov, Taekyoung Kwak, Xue Yang, Adi N. Poli,Colin Hart, Avishek Bhuniya,Joel Cassel,Andrew Kossenkov, Noam Auslander, Paridhima Sharma, Mark G. Cadungog,Stephanie Jean,
Cancer Researchno. 6_Supplement (2024): 5274-5274
Hao Nie,Pratima Saini,Heng Liu,Wei Zhou,Chen Wang, Daniel Claiborne,Nan Zhang,Mohamed Abdel-Mohsen,Rugang Zhang
CANCER RESEARCHno. 5 (2024)
Hao Nie,Pratima Saini, Taito Miyamoto, Liping Liao, Rafal J Zielinski,Heng Liu, Wei Zhou,Chen Wang,Brennah Murphy, Martina Towers, Tyler Yang,Yuan Qi,
Nature communicationsno. 1 (2024): 2853-2853
CANCER LETTERS (2024)
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Brennah Murphy,Taito Miyamoto,Bryan Manning,Toshitha Kannan, Anastasia Ghilkovsky,Yulia Nefedova, Daniel Claiborne,Rugang Zhang,Andrew Kossenkov,Nan Zhang
CANCER RESEARCHno. 5 (2024)
Xue Hao,Bo Zhao, Martina Towers,Liping Liao, Edgar Luzete Monteiro, Xin Xu, Christina Freeman, Hongzhuang Peng,Hsin-Yao Tang,Aaron Havas,Andrew V. Kossenkov,Shelley L. Berger,
Nature Agingno. 2 (2024): 1-13
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