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The main focus of my research is to study prenatal B lymphopoiesis in order to understand the origins of childhood leukaemia, in particular infant acute lymphoblastic leukaemia (ALL). Prenatal B lymphopoiesis is different from adult B cell development; and developmentally-regulated characteristics of fetal B-progenitors are likely to provide the 'oncogenic' cellular context necessary to co-operate with MLL rearrangements to induce infant ALL. We have recently defined the B lymphoid developmental hierarchy before birth, and my research aims to identify the target cell population for leukaemia initiation in infant ALL. Characterisation of the target cell by molecular and functional assays, including developmental differences when compared to postnatal cells, will allow us to identify specific pathways that can be targeted for future therapies. I am also a member of Prof Irene Roberts’ team investigating how trisomy 21 perturbs haematopoiesis before birth and its implications for Down syndrome associated leukaemias in children.
研究兴趣
论文共 92 篇作者统计合作学者相似作者
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Frontiers in cell and developmental biology (2024): 1372899-1372899
Journal of Immunologyno. 1 (2023): 65.16-65.16
Experimental Hematology (2023): S26-S26
Deena Iskander,Noémi B A Roy,Elspeth Payne,Emma Drasar, Kelly Hennessy,Yvonne Harrington,Chrysi Christodoulidou,Anastasios Karadimitris, Leisa Batkin,Josu de la Fuente
Blood reviews (2023): 101097-101097
Mariana Quiroga Londono,Nicole Mende,Emily Stephenson,Deena Iskander,Tomoya Isobe,Simone Webb,Issac Goh, Vijaya Mahalingam Shanmugiah,Rebecca Hannah,Anindita Roy,Irene Roberts,Elisa Laurenti,
EXPERIMENTAL HEMATOLOGY (2023): S129-S129
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Mariana Quiroga Londoño,Nicole Mende,Emily Stephenson,Deena Iskander,Tomoya Isobe,Simone Webb,Issac Goh, Vijaya Mahalingam Shanmugiah,Rebecca Hannah,Anindita Roy,Irene Roberts,Elisa Laurenti,
Experimental Hematology (2023): S129-S129
Bloodno. 20 (2023): 1752-1756
CANCER DISCOVERYno. 2 (2023): 364-385
Hongwei Ren,Natalina Elliott, Bryan Lye M. Phil, Joe Cross, Lucy Field,Kanagaraju Ponnusamy,Irene Roberts,Christina Halsey,Thomas Arthur Milne,Anindita Roy,Anastasios Karadimitris
BLOOD (2023): 766
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