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Our interest in the Cell Tox group is primarily in tumor metabolism, especially in glycerophospholipid and choline metabolic pathways and how their deregulation contribute to disease. Because of my past work in glutathione metabolism and transport via multidrug-resistant transporters in cancer, I am also interested in understanding how redox regulation and stress signaling influence cell behavior.
Our recent work in tumor metabolism, began with the identification of an enzyme, GPCPD1 (EDI3), which we showed to be elevated in primary tumors of endometrial cancer patients who went on to develop metastasis. Ongoing work showed that GPCPD1 produces two products - choline and glycerol-3-phosphate - that serve as building blocks for downstream metabolic pathways. Manipulating levels of GPCPD1 in different tumor cells also influences cell behavior, including cell migration and viability.
Current work continues to characterize GPCPD1 using in vivo tumor models to study its role in tumor development and metastasis, a Gpcpd1 knock out mouse designed with Crispr/Cas9 to understand its physiological role, and mutations to its carbohydrate binding domain to study its potential role in glycogen metabolism. A second major project focuses on glycerophospholipid metabolism in different cancer types, more specifically breast and ovarian cancer, and combines clinical data, both publicly available and self-generated, with metabolite, as well as both in vivo and in vitro data, with the goal to decipher a role for this pathway in tumor development and progression.
Our recent work in tumor metabolism, began with the identification of an enzyme, GPCPD1 (EDI3), which we showed to be elevated in primary tumors of endometrial cancer patients who went on to develop metastasis. Ongoing work showed that GPCPD1 produces two products - choline and glycerol-3-phosphate - that serve as building blocks for downstream metabolic pathways. Manipulating levels of GPCPD1 in different tumor cells also influences cell behavior, including cell migration and viability.
Current work continues to characterize GPCPD1 using in vivo tumor models to study its role in tumor development and metastasis, a Gpcpd1 knock out mouse designed with Crispr/Cas9 to understand its physiological role, and mutations to its carbohydrate binding domain to study its potential role in glycogen metabolism. A second major project focuses on glycerophospholipid metabolism in different cancer types, more specifically breast and ovarian cancer, and combines clinical data, both publicly available and self-generated, with metabolite, as well as both in vivo and in vitro data, with the goal to decipher a role for this pathway in tumor development and progression.
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论文共 135 篇作者统计合作学者相似作者
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Rosemarie Marchan, Bettina Büttner, Jörg Lambert,Karolina Edlund, Iris Glaeser,Meinolf Blaszkewicz,Gregor Leonhardt, Lisa Marienhoff, Darius Kaszta, Moritz Anft,Carsten Watzl,Katrin Madjar,
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Rosemarie Marchan, Bettina Büttner, Jörg Lambert,Karolina Edlund, Iris Glaeser,Meinolf Blaszkewicz,Gregor Leonhardt, Lisa Marienhoff, Darius Kaszta, Moritz Anft,Carsten Watzl,Katrin Madjar,
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FRONTIERS IN PHARMACOLOGY (2023): 1279357-1279357
Mohammad Alwahsh,Robert Knitsch,Rosemarie Marchan,Jörg Lambert, Elen Tolstik,Hannes Raschke, Dina Mahadaly,Alexander Marx,Djeda Belharazem,Roland Hergenröder
Jordan Journal of Pharmaceutical Sciencesno. 2 (2023): 472-472
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Chemico-biological interactions (2023): 110699-110699
Rosemarie Marchan, Bettina Büttner, Jörg Lambert,Karolina Edlund, Iris Glaeser,Meinolf Blaszkewicz,Gregor Leonhardt, Lisa Marienhoff, Darius Kaszta, Moritz Anft,Carsten Watzl,Katrin Madjar,
crossref(2023)
Rosemarie Marchan, Bettina Büttner, Jörg Lambert,Karolina Edlund, Iris Glaeser,Meinolf Blaszkewicz,Gregor Leonhardt, Lisa Marienhoff, Darius Kaszta, Moritz Anft,Carsten Watzl,Katrin Madjar,
crossref(2023)
Rosemarie Marchan, Bettina Büttner, Jörg Lambert,Karolina Edlund, Iris Glaeser,Meinolf Blaszkewicz,Gregor Leonhardt, Lisa Marienhoff, Darius Kaszta, Moritz Anft,Carsten Watzl,Katrin Madjar,
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