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Research Interests
Project 1. We study the role of the microcirculation in the adipose tissue inflammation of the overweight/obese organism to: a) understand how nutrients and excessive calorie intake activates inflammatory signaling cascades in adipose tissue, and b) to find therapeutic targets to averts the metabolic and cardiovascular complications of obesity.
Project 2. Regulation of endothelial function by Calpain. Specifically, we study the impact of calpaan activation on eNOS and endothelial cell adhesion molecule expression levels and functions. We have established the calpain system as an important modulator of endothelial function in insulin resistance and hyperglycemia.
Project 3. We are interested in exploring the main signaling pathways through which physiological aging impairs key function of the vascular endothelium. The overall goal of this research is to find therapeutic targets to offset or delay cardiovascular disease and organ dysfunction in the aging organism.
Project 1. We study the role of the microcirculation in the adipose tissue inflammation of the overweight/obese organism to: a) understand how nutrients and excessive calorie intake activates inflammatory signaling cascades in adipose tissue, and b) to find therapeutic targets to averts the metabolic and cardiovascular complications of obesity.
Project 2. Regulation of endothelial function by Calpain. Specifically, we study the impact of calpaan activation on eNOS and endothelial cell adhesion molecule expression levels and functions. We have established the calpain system as an important modulator of endothelial function in insulin resistance and hyperglycemia.
Project 3. We are interested in exploring the main signaling pathways through which physiological aging impairs key function of the vascular endothelium. The overall goal of this research is to find therapeutic targets to offset or delay cardiovascular disease and organ dysfunction in the aging organism.
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Steven J Forrester,Kyle J Preston,Hannah A Cooper,Michael J Boyer, Kathleen M Escoto, Anthony J Poltronetti,Katherine J Elliott,Ryohei Kuroda,Masashi Miyao,Hiromi Sesaki,Tomoko Akiyama,Yayoi Kimura,
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