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She initially led a group that laid the foundation to understand the pharmacokinetics and toxicology of antisense oligonucleotides (ASOs).
From 2000-2020, she was responsible for building and leading the Cardiovascular, Metabolic and Renal Disease Drug Discovery Group at Ionis.
As vice president, she pioneered the use of antisense oligonucleotide therapeutics for the treatment of dyslipidemias, NASH, hypertension, heart, and kidney disease, culminating in over 10 human development candidates evaluated in clinical trials, with 2 achieving commercial approval (KYNAMRO® and WAYLIVRA®).
Other antisense drugs advancing in the clinic, which all use more advanced and potent chemistries targeting the liver, include pelacarsen, targeting apo(a), vupanorsen, targeting angiopoietin-like protein 3, ION449, targeting PCSK9, IONIS-APOC-III-LRx, the follow-on drug to WAYLIVRA®, IONIS-AGT-LRx, designed to inhibit angiotensinogen, and ION839, an inhibitor to PNPLA3.
Dr. Crooke is a member of the American Heart Association and has also served on the board of the Deuel Conference and the Akcea Therapeutics Scientific Advisory Board.
From 2000-2020, she was responsible for building and leading the Cardiovascular, Metabolic and Renal Disease Drug Discovery Group at Ionis.
As vice president, she pioneered the use of antisense oligonucleotide therapeutics for the treatment of dyslipidemias, NASH, hypertension, heart, and kidney disease, culminating in over 10 human development candidates evaluated in clinical trials, with 2 achieving commercial approval (KYNAMRO® and WAYLIVRA®).
Other antisense drugs advancing in the clinic, which all use more advanced and potent chemistries targeting the liver, include pelacarsen, targeting apo(a), vupanorsen, targeting angiopoietin-like protein 3, ION449, targeting PCSK9, IONIS-APOC-III-LRx, the follow-on drug to WAYLIVRA®, IONIS-AGT-LRx, designed to inhibit angiotensinogen, and ION839, an inhibitor to PNPLA3.
Dr. Crooke is a member of the American Heart Association and has also served on the board of the Deuel Conference and the Akcea Therapeutics Scientific Advisory Board.
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Yuanyuan Qin,Flora Ting,Mee J Kim, Jacob Strelnikov,Joseph Harmon,Feng Gao,Andrea Dose,Ba-Bie Teng, M Amir Alipour,Zemin Yao,Rosanne Crooke,Ronald M Krauss,
Jenny E. Kanter,Baohai Shao,Farah Kramer,Shelley Barnhart, Masami, Shimizu-Albergine,Tomas Vaisar,Mark J. Graham,Rosanne M. Crooke,Clarence R. Manuel,Rebecca A. Haeusler,Daniel Mar,
semanticscholar(2019)
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