基本信息
浏览量:0
职业迁徙
个人简介
My research has focused on gene transfer to the nervous system both to treat animal models of neurological disorders and to model neurological disorders. The bulk of my research has focused on Parkinson’s disease. During my second stint at Wallenberg Neuroscience Center, we developed and validated the nigral rAAV-α-synuclein model of Parkinson’s disease. In collaboration with Nicholas Muzyczka, we have continued to use rAAV vectors to study the basic biology of α-synuclein in substantia nigra both by studying various forms of α-synuclein and by knocking down α-synuclein via shRNAs. I have done the most work on rAAV mediated GDNF delivery for the treatment of PD. More recently, I have branched out to gene therapy for many neurological disorders. Currently, I am using rAAV delivered DREADDs to study the basal ganglia circuits involved in repetitive behaviors which may be related to autism.
研究兴趣
论文共 66 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Parkinson's Disease, Second Editionpp.1119-1148, (2012)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn