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职业迁徙
个人简介
Research Interests
NMR spectroscopy, structural biology, metabolomics, bioinformatics, drug discovery
Nuclear Magnetic Resonance (NMR) spectroscopy has proven itself an extremely versatile tool for exploring a variety of biological problems. NMR has been successfully used to determine the structure of numerous biomolecules, investigate biomolecular interactions, screen for potential drugs, determine structures of drug-complexes, monitor in vivo drug activity and analyze blood and urine for drug toxicity. As a result, NMR is widely used in the pharmaceutical industry to aid in drug discovery efforts. My research interest is focused on the application and development of NMR methodologies to understand the structure, function and evolution of novel proteins and their corresponding therapeutic utility in structure-based drug design programs.
Examples of some of our recent NMR protein structures. (A) Archaeglobus fulgidis peptidyl-tRNA hydrolase, (B) Pseudomonas putida protein PpPutA45 and its DNA complex, (C) Pseudomonas aeruginosa protein PA1324, (D) protein YndB from Bacillus subtilis, (E) Staphylococcus aureus C-terminal domain of primase, and (F) J-domain of human DNAJA1.
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论文共 347 篇作者统计合作学者相似作者
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Goncalo Jorge Gouveia, Thomas Head,Leo L. Cheng,Chaevien S. Clendinen,John R. Cort,Xiuxia Du,Arthur S. Edison, Candace C. Fleischer,Jeffrey Hoch,Nathaniel Mercaldo,Wimal Pathmasiri,Daniel Raftery,
Susan T. Ovbude,Sadia Sharmeen,Isaac Kyei, Harshana Olupathage, Jacob Jones, Richard J. Bell,Robert Powers,David S. Hage
Nature cell biologypp.1-1, (2024)
Robert Powers,Erik R. Andersson, Amanda L. Bayless,Robert B. Brua,Mario C. Chang,Leo L. Cheng,Chaevien S. Clendinen, Darcy Cochran,Valerie Copie,John R. Cort, Alexandra A. Crook,Hamid R. Eghbalnia,
TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024): 117478
Nature Cell Biologypp.1-15, (2024)
ACS CHEMICAL NEUROSCIENCEno. 6 (2024): 1110-1124
Emilia Przygrodzka, Fatema Binderwala,Robert Powers,Renee M McFee,Andrea S Cupp,Jennifer R Wood,John S Davis
bioRxiv : the preprint server for biology (2024)
Biopolymersno. 1 (2023): e23534-e23534
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