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My main personal research interest is in innate and adaptive immune regulation during health and in disease, which I have studied for the last twenty-five years. I have investigated this in autoimmune thyroiditis (1992-98) and CD8+ T cell homeostasis, focusing on its role in graft rejection (1999-2004) with the support of the American Heart Association. Here my contributions to science included evaluation of the regulation of allo- and auto-reactive T cells. There is a clinical need for achieving tolerance during autoimmunity and allotransplantation. I studied the role of incomplete antigen stimulation in producing tolerized and regulatory T cells. I utilized two novel in vivo systems to achieve this:1) I first defined the role of non-professional antigen presenting cells in regulating antigen-specific autoimmune thryroiditis, and 2) engineered soluble MHC Class I tetramers and first described molecular (including co-receptor dependence and CD8+ Foxp3+ expression) and cellular mechanisms (intra-antigen specificity regulation of CD8+ T cells) of dynamically “tuned” cytotoxic CD8+ T cell responses in models of skin transplantation and peripheral tolerance in autoimmunity.
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Frontiers in immunology (2023): 1188830
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Jennifer A Munley, Micah L Willis,Gwendolyn S Gillies, Kolenkode B Kannan, Valerie E Polcz,Jeremy A Balch, Evan L Barrios,Shannon M Wallet, Letitia E Bible,Philip A Efron, Robert Maile,Alicia M Mohr
The journal of trauma and acute care surgeryno. 4 (2023): 548-556
Journal of leukocyte biologyno. 5 (2023): 384-386
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Cressida Mahung,Wesley H Stepp,Clayton Long,Madison Malfitano, Irmak Saklayici,Shannon M Wallet, Laura Y Zhou,Haibo Zhou,Bruce A Cairns,Robert Maile
The journal of trauma and acute care surgeryno. 5 (2022): 702-711
Cressida Mahung,Shannon M Wallet, Jordan E Jacobs,Laura Y Zhou,Haibo Zhou,Bruce A Cairns,Robert Maile
medRxivno. 4 (2022): e0267353-e0267353
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