Robert L. Tansik

Dept. of Pharmacology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709, USA

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Papers14 papers

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ChemInform Abstract: Inhibitors of Dihydrofolate Reductase: Design, Synthesis and Antimicrobial Activities of 2,4-Diamino-6-methyl-5-ethynylpyrimidines

Michael L. Jones,David P. Baccanari,Robert L. Tansik,Christine M. Boytos,Sharon K. Rudolph,Lee F. Kuyper

Cheminform, no. 27 (2010)

Bibtex

Preclinical Development of Eniluracil: Enhancing the Therapeutic Index and Dosing Convenience of 5-Fluorouracil

Melanie T. Paff,David P. Baccanari,Stephen T. Davis,Shousong Cao,Robert L. Tansik,Youcef M. Rustum,Thomas Spector

Investigational New Drugs, no. 4 (2000): 365-371

Cited by6WOSBibtex

α-Fluoro-β-alanine: Effects on the antitumor activity and toxicity of 5-fluorouracil

Shousong Cao,David P Baccanari,Youcef M Rustum,Stephen T Davis,Robert L Tansik,David J.T Porter,Thomas Spector

BIOCHEMICAL PHARMACOLOGY, no. 8 (2000): 953-960

Cited by17EIBibtex

Inhibitors of dihydrofolate reductase: Design, synthesis and antimicrobial activities of 2,4-diamino-6-methyl-5-ethynylpyrimidines

Michael L. Jones,David P. Baccanari,Robert L. Tansik,Christine M. Boytos,Sharon K. Rudolph,Lee F. Kuyper

Journal of Heterocyclic Chemistry, no. 1 (1999): 145-148

Cited by2Bibtex

Synthesis of 1,3-diamino-7,8,9,10-tetrahydropyrido[3,2-f]-quinazolines. Inhibitors ofCandida albicansdihydrofolate reductase as potential antifungal agents

Joseph H. Chan,David P. Baccanari,Robert L. Tansik,Christine M. Boytos,Sharon K. Rudolph,Andrew D. Brown,Jean S. Hong,Lee F. Kuyper,Michael L. Jones

Journal of Heterocyclic Chemistry, no. 1 (1997): 145-151

Cited by3Bibtex

STRUCTURES OF CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE: HOLOENZYME AND TERNARY INHIBITOR COMPLEXES

Marc Whitlow,Andrew J. Howard,David Stewart,Karl D. Hardman,Lee F. Kuyper,David P. Baccanari,Mary Fling,Joseph H. Chan,Robert L. Tansik

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, no. SUPnan (1996): C208-C209

Bibtex

Structures of Candida albicans dihydrofolate reductase: holoenzyme and ternary inhibitor complexes

K D Hardman,Lee F Kuyper,David P Baccanari,M E Fling,Joseph H Chan,Robert L Tansik, D B Stewart,Marc D Whitlow,A J Howard

Acta Crystallographica Section A, (1996)

Bibtex

Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines

J H Chan,J S Hong,L F Kuyper,D P Baccanari,S S Joyner,R L Tansik,C M Boytos,S K Rudolph

Journal of medicinal chemistry, no. 18 (1995): 3608-3616

Cited by8WOSBibtex

Synthesis of 5-(4-substituted benzyl)-2,4-diaminoquinazolines as inhibitors ofcandida albicansdihydrofolate reductase

G. Erik Jagdmann,Joseph H. Chan,Virgil L. Styles,Robert L. Tansik,Christine M. Boytos,Sharon K. Rudolph

Journal of Heterocyclic Chemistry, no. 5 (1995): 1461-1465

Bibtex

Substrate-inhibitor cooperative interactions with microbial dihydrofolate reductases

D.P. Baccanari,R.L. Tansik,G.H. Hitchings

ADVANCES IN ENZYME REGULATION, (1987): 3-15

Cited by2EIWOSBibtex

Kinetics of methotrexate binding to dihydrofolate reductase from Neisseria gonorrhoeae

David P. Baccanari,Robert L. Tansik

BIOCHEMICAL PHARMACOLOGY, no. 13 (1984): 2101-2107

Cited by1EIWOSBibtex

Effects of Δ9-tetrahydrocannabinol and cannabidiol on phospholipase and other enzymes regulating arachidonate metabolism

Helen L. White,Robert L. Tansik

Prostaglandines and Medicine, no. 6 (1980): 409-417

EIBibtex

Prostaglandin synthesis in homogenates of cultured neuroblastoma cells

Robert L. Tansik,Helen L. White

Prostaglandines and Medicine, no. 3 (1979): 225-234

Cited by18EIWOSBibtex

Synthesis of prostaglandin 6-keto F1α by cultured aortic smooth muscle cells and stimulation of its formation in a coupled system with platelet lysates

Robert L. Tansik,Donald H. Namm,Helen L. White

Prostaglandins, no. 3 (1978): 399-408

Cited by44EIWOSBibtex

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