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The Cartilage Tissue Engineering lab studies articular cartilage, synovial fluid, and synovial joints with the ultimate goal of improving the treatment, diagnosis, and prevention of osteoarthritis. Studies of human joints, tissues, and fluids seek to delineate the natural sequence of degenerative events that occur in aging, after injury, and during the progression of osteoarthritis. Studies of tissue models examine the mechanisms by which mechanical and chemical stimuli modulate cartilage metabolism, and lead to tissue maintenance, growth, or deterioration. Studies of engineered tissues, targeting cartilage, bone, and the cartilage-bone interface, seek to develop treatments for damaged cartilage and also to understand growth and maturation processes. Studies of engineered fluid seek to understand the physiology of the lubricating nature of synovial joint fluid. Finally, translational studies seek to determine whether and how engineered materials can effectively treat damaged cartilage. The lab utilizes a variety of biochemical, cellular, molecular, histological, imaging and image processing methods.
The Cartilage Tissue Engineering lab studies articular cartilage, synovial fluid, and synovial joints with the ultimate goal of improving the treatment, diagnosis, and prevention of osteoarthritis. Studies of human joints, tissues, and fluids seek to delineate the natural sequence of degenerative events that occur in aging, after injury, and during the progression of osteoarthritis. Studies of tissue models examine the mechanisms by which mechanical and chemical stimuli modulate cartilage metabolism, and lead to tissue maintenance, growth, or deterioration. Studies of engineered tissues, targeting cartilage, bone, and the cartilage-bone interface, seek to develop treatments for damaged cartilage and also to understand growth and maturation processes. Studies of engineered fluid seek to understand the physiology of the lubricating nature of synovial joint fluid. Finally, translational studies seek to determine whether and how engineered materials can effectively treat damaged cartilage. The lab utilizes a variety of biochemical, cellular, molecular, histological, imaging and image processing methods.
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Advances in Experimental Medicine and Biology (2023): V-VIII
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International journal of nanomedicine (2023): 4171-4191
Hema Kalyanaraman,Shyamsundar Pal China, Justin A Cabriales, Jafar Moininazeri,Darren E Casteel,Julian J Garcia,Van W Wong,Albert Chen,Robert L Sah,Gerry R Boss,Renate B Pilz
Laurent Fattet,Hae-Yun Jung,Mike W Matsumoto, Brandon E Aubol,Aditya Kumar,Joseph A Adams,Albert C Chen,Robert L Sah,Adam J Engler,Elena B Pasquale,Jing Yang
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