基本信息
浏览量:83
职业迁徙
个人简介
The research goals of Robert J. Pignolo, M.D., Ph.D., are to understand the mechanisms underlying skeletal aging, and to use insights from rare bone diseases to inform new ways of studying and treating conditions of skeletal dysfunction. Dr. Pignolo's work has relevance to stem cell biology, regenerative medicine and the influence of micro-environmental effects on cellular aging.
Focus areas
Aging of bone. Dr. Pignolo has developed approaches and methods that have enabled investigations into the osteobiology of aging. He established a method for confirming the existence of dysfunctional telomeres in aging bone, which suggests the likelihood that cellular senescence plays a contributory role in age-related bone loss. He studies the cellular and micro-environmental basis for bone aging.
Mesenchymal stem cell biology. Dr. Pignolo has demonstrated that functional reconstitution by young stem cells in vivo delays aspects of accelerated bone aging and may extend lifespan. He also identified vibration-induced bone-enhancing (vibe) genes in stem cells, as proof-of-principle for development of anabolic agents to promote bone and muscle strength.
Circulating osteogenic precursor (COP) cells. Dr. Pignolo first described COP cells as hematopoietic-derived cells with osteogenic potential that can seed sites of inflammation. He works to discover how these cells contribute to diverse conditions such as extraskeletal bone formation and end-stage aortic valvular disease.
Disorders of extraskeletal bone formation. Dr. Pignolo examines the natural history and early lesion formation in rare diseases of ectopic bone formation. He is a principal investigator of the first industry-funded clinical trial of the retinoic acid receptor agonist palovarotene for the treatment of fibrodysplasia ossificans progressiva (FOP).
Significance to patient care
The work performed by Dr. Pignolo has tremendous clinical implications for age-related osteoporosis, fractures, various conditions of disease-associated bone loss, rare bone diseases such as FOP, common conditions of heterotopic bone formation, frailty and sarcopenia.
Focus areas
Aging of bone. Dr. Pignolo has developed approaches and methods that have enabled investigations into the osteobiology of aging. He established a method for confirming the existence of dysfunctional telomeres in aging bone, which suggests the likelihood that cellular senescence plays a contributory role in age-related bone loss. He studies the cellular and micro-environmental basis for bone aging.
Mesenchymal stem cell biology. Dr. Pignolo has demonstrated that functional reconstitution by young stem cells in vivo delays aspects of accelerated bone aging and may extend lifespan. He also identified vibration-induced bone-enhancing (vibe) genes in stem cells, as proof-of-principle for development of anabolic agents to promote bone and muscle strength.
Circulating osteogenic precursor (COP) cells. Dr. Pignolo first described COP cells as hematopoietic-derived cells with osteogenic potential that can seed sites of inflammation. He works to discover how these cells contribute to diverse conditions such as extraskeletal bone formation and end-stage aortic valvular disease.
Disorders of extraskeletal bone formation. Dr. Pignolo examines the natural history and early lesion formation in rare diseases of ectopic bone formation. He is a principal investigator of the first industry-funded clinical trial of the retinoic acid receptor agonist palovarotene for the treatment of fibrodysplasia ossificans progressiva (FOP).
Significance to patient care
The work performed by Dr. Pignolo has tremendous clinical implications for age-related osteoporosis, fractures, various conditions of disease-associated bone loss, rare bone diseases such as FOP, common conditions of heterotopic bone formation, frailty and sarcopenia.
研究兴趣
论文共 244 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Biomoleculesno. 2 (2024): 147
Vitali Lounev,Jay C Groppe,Niambi Brewer, Kelly L Wentworth, Victoria Smith,Meiqi Xu, Lutz Schomburg, Pankaj Bhargava, Mona Al Mukaddam,Edward C Hsiao,Eileen M Shore,Robert J Pignolo,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (2024)
Future Rare Diseases (2024)
Dominik Saul,Madison L Doolittle,Jennifer L Rowsey, Mitchell N Froemming, Robyn L Kosinsky,Stephanie J Vos,Ming Ruan,Nathan LeBrasseur,Abhishek Chandra,Robert Pignolo,João F Passos,Joshua N Farr,
bioRxiv : the preprint server for biology (2024)
Mayo Clinic Proceedingsno. 2 (2024): 318-335
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 284-284
引用0浏览0引用
0
0
M. Al Mukaddam,G. Baujat,A.M. Cheung,C. De Cunto,E.C. Hsiao,R. Keen, J. Marden, J. Signorovitch, E. Boing,R. Marino,A. Strahs,R.J. Pignolo
引用0浏览0引用
0
0
bioRxiv (Cold Spring Harbor Laboratory) (2023)
MAYO CLINIC PROCEEDINGSno. 4 (2023): 502-503
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 171-172
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn