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In 1986 Dr. Lefkowitz transformed the understanding of what had by then become known as G protein coupled receptors because of the way the receptor signal for the inside of a cell through G proteins, when he and his colleagues cloned the gene for the beta2-adrenergic receptor. They immediately recognized the similarity to a molecule called rhodopsin which is essentially a light receptor in the retina. This unexpected finding established the beta receptor and rhodopsin as the first member of a new family of proteins. Because each has a peptide structure, which weaves across the cell membrane seven times, these receptors are referred to as seven transmembrane receptors. This super family is now known to be the largest, most diverse and most therapeutically accessible of all the different kinds of cellular receptors. There are almost a thousand members of this receptor family and they regulate virtually all known physiological processes in humans. They include the receptors not only to numerous hormones and neurotransmitters but for the receptors which mediate the senses of sweet and bitter taste and smell amongst many others. Dr. Lefkowitz also discovered the mechanism by which receptor signaling is turned off, a process known as desensitization.
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论文共 1426 篇作者统计合作学者相似作者
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Howard A Rockman,Robert J Lefkowitz
The Journal of clinical investigationno. 5 (2024)
Marina Casiraghi,Haoqing Wang, Patrick Brennan, Chris Habrian,Harald Hübner, Maximilian F. Schmidt, Luis Maul,Biswaranjan Pani, Sherif M.F.M. Bahriz, Bing Xu, Elizabeth White,Roger K. Sunahara,
biorxiv(2024)
Marina Casiraghi,Haoqing Wang, Patrick Brennan,Chris Habrian,Harald Hubner,Maximilian F Schmidt, Luis Maul,Biswaranjan Pani, Sherif MFM Bahriz,Bing Xu, Elizabeth White,Roger K Sunahara,
crossref(2024)
Marina Casiraghi,Haoqing Wang, Patrick Brennan,Chris Habrian,Harald Hübner,Maximilian F Schmidt, Luis Maul,Biswaranjan Pani, Sherif M F M Bahriz,Bing Xu, Elizabeth White,Roger K Sunahara,
bioRxiv : the preprint server for biology (2024)
Circulation Researchno. Suppl_1 (2023)
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Evi Kostenis,Jesus Gomeza, Elke Miess-Tanneberg,Nina Kathleen Blum, Tobias Benkel, Andy Chevigné, Carsten Hoffmann,Peter Kolb, Viacheslav Nikolaev, Maria Waldhoer, Martyna Szpakowska, Asuka Inoue,
Nature Communicationsno. 1 (2023): 7866-7866
Alem W. Kahsai, Kunal S. Shah,Paul J. Shim, Mason A. Lee, Bowie N. Shreiber,Allison M. Schwalb, Xingdong Zhang, Henry Y. Kwon,Li-Yin Huang,Erik J. Soderblom,Seungkirl Ahn,Robert J. Lefkowitz
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 43 (2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 43 (2023)
Alyssa Grogan,Seungkirl Ahn,David Israel,Alex Shaginian,Qiuxia Chen, Jian Liu, Max Wilkey,Jialu Wang,Alem Kahsai,Robert J. Lefkowitz,Howard A. Rockman
CIRCULATION RESEARCH (2023)
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