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Our research focuses on the metabolic pathways that (1) provide molecules essential for the normal function of the retina and (2) protect against stress-induced retinal degenerations. Disruptions in the former, which occurs in dominantly inherited Stargardt-like Macular Dystrophy (STGD3), leads to macular degeneration in children. We recently discovered that a unique group of fatty acids found primarily in photoreceptor membranes is greatly reduced in retinas of an animal model of STGD3. Current studies are focused on finding ways to deliver these essential fatty acids to the retina with the goal of preventing the retinas from degenerating. Environmental and hereditary stresses can lead to retinal degeneration. We discovered that the insulin receptor can be activated by light and initiate a series of “downstream” reactions that can protect the retina from light stress-induced degeneration. Current studies are focused on finding ways to fortify these pathways so that the retinas of persons susceptible to retinal diseases become more resistant to stress-induced degeneration. Finally, we have identified a number of synthetic and naturally occurring compounds that can protect the retina from oxidant stress-induced degeneration. Current research focuses on identifying the specific metabolic pathways these compounds affect and to test their efficacy in animal models of human age-related macular degeneration.
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Martin-Paul Gameli Agbaga, Daniel J. Stein,Richard Brush,Vicki Ea,Neeraj Kumar Chauhan,Lea Bennett, Brian Rohrs,Robert E. Anderson
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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Theodoros Grigoratos,Athanasios Mamakos,Michael Arndt,Dmytro Lugovyy,Robert Anderson, Christian Hafenmayer, Mikko Moisio,Joonas Vanhanen,Richard Frazee,Carlos Agudelo,Barouch Giechaskiel
ATMOSPHEREno. 1 (2023): 103-103
Tereza Honzikova,Martin-Paul Agbaga,Robert Eugene Anderson,Richard Brush,Mohiuddin Ahmad, Lenka Musilkova, Karolina Sejstalova,Katsiaryna Alishevich, Radek Benes, Petra Simicova,Marketa Bercikova,Vladimir Filip,
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRYno. 46 (2023): 17909-17923
The American Journal of the Medical Sciences (2023): S396-S397
Robert E. Anderson, Albert P. Berg, James R. Carter, Dana M. DeFrancesco, Ronald W. Elliott,Jessica L. Gregris, Donald W. Hershberger, William Y. Joo,Dahesh A. Khalil, Jeremy R. Kozee, Philip C. Minor, Pamela A. Phillips,
Research Square (Research Square) (2021)
Research Square (Research Square) (2021)
Wesley Vandiver,Robert Anderson
SAE Technical Paper Series (2021)
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