My research is embedded in the University Center for Psychiatry at the University Medical Center Groningen. It focuses on the prevention and treatment of Mood and Anxiety Disorders, with depression as a central theme. My aim is to develop more effective interventions based on a better understanding of underlying mechanisms, both on psychological/social and neurobiological level. With a background in epidemiology, I work in patient cohorts such as the Netherlands Study of Depression and Anxiety (NESDA), population studies such as LIFELINES and TRAILS, but we also developed the psychiatry iLab focusing on capturing individual symptom profiles in relation to context. As such, we perform both small high intensive individualised pilot studies and much larger clinical (multi-site) trials. Pathophysiological mechanisms of interest include neuroinflammation and chronobiology, and more recently my group explores the therapeutic potential of novel (or not so novel) psychoplastic compounds such as ketamine and psilocybin for patients with hard to treat depression and other severe mental illnesses. As a clinician and supervisor I work in our Academic Mood Disorders program.