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职业迁徙
个人简介
We are interested in neural stem cell (NSC) behaviours in developing and adult organisms, addressing questions such as:
How do they switch “off” and “on” (quiescence and reactivation)?
How many times can they divide?
How do they give rise to appropriate numbers of appropriate cell types?
Can we manipulate numbers and fates of their progeny in a way that is both safe and useful?
What makes the difference between increasing their proliferative capacity and tipping them into uncontrolled proliferation and cancer?
We compare and contrast normal NSC behaviours with those of glioblastoma stem cells (GSCs), which are NSC-like. We hope to discover vulnerabilities in these that might be exploited in novel approaches to combat this devastating disease. Specifically, we are addressing GSC quiescence, which protects these cells from current therapeutics.
How do they switch “off” and “on” (quiescence and reactivation)?
How many times can they divide?
How do they give rise to appropriate numbers of appropriate cell types?
Can we manipulate numbers and fates of their progeny in a way that is both safe and useful?
What makes the difference between increasing their proliferative capacity and tipping them into uncontrolled proliferation and cancer?
We compare and contrast normal NSC behaviours with those of glioblastoma stem cells (GSCs), which are NSC-like. We hope to discover vulnerabilities in these that might be exploited in novel approaches to combat this devastating disease. Specifically, we are addressing GSC quiescence, which protects these cells from current therapeutics.
研究兴趣
论文共 16 篇作者统计合作学者相似作者
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biorxiv(2021)
crossref(2018)
Rachel E Shaw,Benjamin Kottler,Zoe N Ludlow,Edgar Buhl,Dongwook Kim,Sara Morais da Silva, Alina Miedzik, Antoine Coum,James Jl Hodge,Frank Hirth,Rita Sousa-Nunes
The EMBO journalno. 13 (2018)
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D-Core
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