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Dr. Valentino’s research has shown that corticotropin releasing factor (CRF), the orchestrator of the stress response, regulates the activity of the brain monoamine systems. As these systems have been implicated in affective disorders, her studies provide a window into how stress increases vulnerability to these diseases. Her laboratory also studies the neurobiological basis for sex differences and developmental differences in stress reactivity and stress-related disorders. In addition, a branch of her research is focused on central control of pelvic visceral function. To this end, her group identified a neural circuit through which pelvic visceral activity and cortical activity are coordinated and that may also account for the comorbidity of psychiatric and pelvic visceral symptoms.
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IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
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Journal of neural transmission (Vienna, Austria : 1996)pp.1-7, (2023)
Wen G. Chen,Dana Schloesser,Angela M. Arensdorf, Janine M. Simmons,Changhai Cui,Rita Valentino,James W. Gnadt,Lisbeth Nielsen, Coryse St. Hillaire-Clarke, Victoria Spruance,Todd S. Horowitz, Yolanda F. Vallejo,
TRENDS IN NEUROSCIENCESno. 1 (2021): 3-16
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