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The workgroup of Rik de Swart focuses on infections with measles virus, human respiratory syncytial virus (HRSV) and human metapneumovirus (HMPV), with special emphasis on the interactions between virus and immune system and the identification of correlates of protection or disease. The group has used recombinant paramyxoviruses expressing fluorescent reporter proteins to study viral tropism and pathogenesis in cell and tissue culture and in animal models. These studies have resulted in the identification of the predominant target cells of measles virus infection during the early, intermediate and late stages of the disease. In addition, a new model was developed to explain the mechanism of measles immune suppression. Subsequently, follow-up studies resolved the tropism of a live-attenuated measles virus vaccine.
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Katharina S Schmitz, Kim Handrejk, Lelde Liepina,Lisa Bauer,Griffin D Haas, Fabiënne van Puijfelik,Edwin J B Veldhuis Kroeze, Marta Riekstina,Jurgis Strautmanis,Huyen Cao,Robert M Verdijk,Corine H GeurtsvanKessel,
Journal of virologyno. 3 (2024): e0187423-e0187423
JOURNAL OF VIROLOGYno. 3 (2024): e0185023-e0185023
The Journal of general virologyno. 5 (2023)
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JOURNAL OF GENERAL VIROLOGYno. 8 (2023): 1-55
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunologyno. 10 (2023)
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mSphereno. 4 (2023): e0008223-e0008223
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