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The BM microenvironment is a unique cellular architecture which crucially regulates self-renewal and differentiation potential of hematopoietic stem and progenitor cells through cell-cell interaction or the release of soluble mediators. These evolutionary conserved processes that evolved to protect normal hematopoietic stem cells from elimination and to regulate demand-adapted responses during inflammation are frequently hijacked in cancer and leukemia. The goal of our research is to understand the molecular and cellular mechanisms how different components of the BM microenvironment such as immune cells and stromal cells affect disease-initiating and –maintaining leukemia stem cells (LSCs) and protect them from immune-mediated elimination. We take advantage of state-of-the art technologies, well-established chronic and acute myeloid leukemia mouse and patient-derived xenograft models in order strengthen our understanding on LSCs and to translate our findings into human disease.
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论文共 118 篇作者统计合作学者相似作者
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Matteo Bianchi, Christian Reichen, Amelie Croset,Stefanie Fischer, Aline Eggenschwiler, Yvonne Grübler, Rajlakshmi Marpakwar,Thamar Looser, Patricia Spitzli, Christel Herzog,Denis Villemagne, Dieter Schiegg,
Biomaterials (2023): 122126-122126
Roberta Esposito,Andrés Lanzós,Tina Uroda,Sunandini Ramnarayanan,Isabel Büchi,Taisia Polidori,Hugo Guillen-Ramirez, Ante Mihaljevic, Bernard Mefi Merlin,Lia Mela,Eugenio Zoni,Lusine Hovhannisyan,
Nature communicationsno. 1 (2023): 5463-5463
HemaSphereno. S3 (2023): e064340f-e064340f
Viviana Rubino, Michelle Hueppi, Sabine Hoepner,Luigi Tortola, Lea Taylor,Irene Keller,Remy Bruggmann,Marie-Noelle Kronig,Ulrike Vera Bacher,Manfred Kopf,Adrian Ochsenbein,Carsten Riether
bioRxiv (Cold Spring Harbor Laboratory) (2023)
HemaSphereno. S3 (2023): e1419848-e1419848
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