Biomarker discovery for pancreatic cystic neoplasms, quantitative imaging analysis for pancreatic cysts and cancer, early detection of pancreatic cancer, prevention of post-ERCP pancreatitis, outcomes of endoscopic therapy for pancreatic disease (pseudocysts, and pancreatic necrosis) and luminal disease (Zenker's diverticulum, Barrett's esophagus, early esophageal cancer, early gastric cancer, early colon cancer, large polyps, esophageal strictures), advanced endoscopic imaging.