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Dr. Stouffer’s research program utilizes whole animal, cellular and molecular approaches to unravel the mechanisms controlling follicle development, ovulation and the functional lifespan of the corpus luteum during the menstrual cycle and early pregnancy in rhesus macaques. One NIH R01 grant (which has been active for over 30 years at Arizona and Oregon!) focuses on the endocrine and local control of the primate ovulatory follicle and corpus luteum. This project resulted in the landmark discovery (Hibbert et al., PNAS 93:1897-1901, 1996, PMID: 8700855) that progesterone produced by the dominant follicle in response to midcycle gonadotropin surge is required for ovulation and development of the primate corpus luteum. The later feature, which differs from the mouse model, is supported by novel studies detailing the expression of genomic progesterone receptor in macaque (and human) luteal cells, and spurred Dr. Stouffer’s important studies to elucidate the gonadotropin (LH or CG)- and progesterone– responsive genes in the ovulatory follicle, as well as the corpus luteum as it ages during the menstrual cycle and early pregnancy (e.g., Xu et al., Mol Hum Reprod 17:152-165, 2011, PMID 21036944; Bishop et al., Mol Hum Reprod 16:216-227, 2012, PMID 22072816). These gene (GED) databases are publicly available, and being used for comparative studies of ovarian function by other investigators. Currently, Dr. Stouffer, in collaboration with Dr. Jon Hennebold, is using attenuated adenoviral vectors to deliver siRNAs to PR and PGRMC1 into the macaque periovulatory follicle to elucidate the role(s) of genomic and nongenomic progesterone receptor signaling pathways in ovulation and corpus luteum development in primates.
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Journal of the Endocrine Societyno. Supplement_1 (2019)
Biology of reproductionno. 2 (2018): 197-207
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