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Lifton has used human genetics and genomics to identify rare mutations with large effect and elucidate biochemical mechanisms underlying diverse common diseases.In the particular case of hypertension, which affects more than a billion people worldwide and is a principal risk factor for heart attack, stroke and heart failure, together the leading cause of death worldwide, Lifton’s work has identified mutations and biochemical mechanisms that drive blood pressure to the highest and lowest blood pressures compatible with survival, implicating altered renal salt reabsorption in blood pressure variation. This work has also identified a previously unrecognized pathway that orchestrates the balance between salt and potassium homeostasis, providing a mechanism for dietary potassium’s ability to lower blood pressure. These findings provided the scientific basis for reducing salt balance in the prevention and treatment of hypertension, strategies that are used worldwide. Finding mutations underlying extreme outliers of common disease to identify pathways that can manipulated for health benefit has been broadly applied.
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论文共 637 篇作者统计合作学者相似作者
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Nature communicationsno. 1 (2023): 7452-23
JAMA neurologyno. 6 (2023): 578-587
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Genome medicineno. 1 (2023): 22-22
Vox sanguinisno. 6 (2023): 440-446
Kedous Y. Mekbib,Shujuan Zhao,Carol Nelson-Williams,Andrew Prendergast,Xue Zeng,Myron Rolle,John Shohfi,Hannah Smith,Jack Ocken, Quentin Moyer, Paulina Piwowarczyk,Garrett Allington,
Neurosurgeryno. Supplement_1 (2023): 22-22
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medRxiv : the preprint server for health sciences (2023)
Syria Laperche,Claire Sauvage,Pierre Gallian, Saadia Jbilou,Elodie Pouchol, Jean Yves Py,Lila Chabli,Pascale Richard,Pascal Morel,Florence Lot,Pierre Tiberghien
Vox sanguinisno. 10 (2023): 843-853
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Gabriel Stölting,Hoang An Dinh, Marina Volkert,Nicole Hellmig,Julia Schewe, Luise Hennicke,Eric Seidel,Herbert Oberacher,Junhui Zhang,Richard P Lifton, Iris Urban,Melissa Long,
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VOX SANGUINIS (2023)
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