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Dr. Locksley's laboratory addresses the immune cells and tissue responses that occur during allergic, or type 2, immunity. This includes the processes by which naïve helper T cells differentiate to become allergy-supporting Th2 cells, but also the interactions of these cells with eosinophils, basophils, mast cells and alternatively activated macrophages that mediate activities in peripheral tissues. The laboratory increasingly focuses on innate immunity, particularly since the discovery of Group 2 innate lymphoid cells, or ILC2s, which are prominently involved in allergy. Importantly, the discovery of ILC2s initiated efforts to uncover the ‘ground state’ of allergy by investigating homeostatic pathways involving these cells that might provide insights regarding their primary function in the immune system and in homeostasis.
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论文共 296 篇作者统计合作学者相似作者
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Akila Rekima,Lieke van den Elsen, Charlotte Isnard,Danielle J. Smyth,Miriam A. Lynn, Tee Yee,Natalie E. Stevens, Savannah Machado, Nivedithaa Divakara, Maheshwar Bhasin,M. Christian Tjiam,Candia Rowel,
Rachel K. Zwick,Petr Kasparek,Brisa Palikuqi, Sara Viragova,Laura Weichselbaum,Christopher S. McGinnis,Kara L. McKinley, Asoka Rathnayake,Dedeepya Vaka,Vinh Nguyen,Coralie Trentesaux, Efren Reyes,
Nature Cell Biologyno. 2 (2024): 250-262
bioRxiv : the preprint server for biology (2023)
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Nature Communicationsno. 1 (2023): 6872-14
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Journal of Immunologyno. 1 (2023): 227.15-227.15
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Immunityno. 4 (2023): 704-722
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