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Sphingolipids, the topic of our research, were named after the mysterious Sphinx of Greek mythology because of their mysterious properties. It is now well-known that a major function for sphingolipids is to serve as building blocks for cell membranes. Because of their distinctive structural characteristics, these molecules form plasma membrane "rafts" and act as binding sites for cells, viruses and toxins.
Sphingolipids also function directly as signaling molecules. Sphingosine-1-phosphate (S1P), a product of sphingolipid degradation, is a regulator of several biological processes. S1P can be produced by all cells and its concentration is relatively high in blood. It has five high-affinity G-protein-coupled receptors (GPCRs) that are highly and widely expressed. S1P signaling through its GPCRs regulates basic functions in the vascular, nervous, and immune systems.
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Aritra Bhattacharyya, Ranjha Khan,Joanna Y. Lee, Gizachew Tassew,Babak Oskouian,Maria L. Allende,Richard L. Proia,Xiaoyang Yin, Javier G. Ortega,Mallar Bhattacharya,Julie D. Saba
JOURNAL OF PATHOLOGY (2024)
MOLECULAR METABOLISM (2024): 101851-101851
Hongling Zhu,Colleen Byrnes,Y Terry Lee,Galina Tuymetova,Hannah B D Duffy, Jenna Y Bakir, Sydney N Pettit, Jabili Angina,Danielle A Springer,Maria L Allende,Mari Kono,Richard L Proia
JOURNAL OF LIPID RESEARCHno. 12 (2023): 100463-100463
Journal of Inherited Metabolic Diseaseno. 4 (2023): 687-694
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