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个人简介
Research interests
The focus of both my clinical and basic research is on optimising endocrine hormone replacement. My group have identified and characterised uncommon mutations in the growth hormone receptor which have led to fundamental observations on the mechanism by which the growth hormone receptor signals through a pre-formed dimer.
This work led to a greater understanding of the regulation of growth hormone secretion and the group have developed a long acting form of growth hormone and this work was published in Nature Medicine in 2007. The group are now actively developing a long acting growth hormone antagonist.
The Clinical Research Programme has been investigating different regimens for replacing cortisol, testosterone and oestrogen in hypopituitary, hypogonadal and adrenal insufficient patients.
研究兴趣
论文共 310 篇作者统计合作学者相似作者
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FRONTIERS IN PHARMACOLOGY (2023): 1090554-1090554
The lancet. Healthy longevityno. 10 (2023): e561-e572
M Tavernier,Callum F. Ross,Craig Jessica, Chamila Balagamage,Brian Keevil,Richard Ross,Miguel Debono,Charlotte Elder
Endocrine Abstracts (2023)
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Endocrine Abstracts (2023)
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Miguel Debono,Charlotte J Elder,Jen Lewis, Jane Fearnside, Sharon Caunt,Simon Dixon,Richard M Jacques,John Newell-Price,Martin J Whitaker,Brian Keevil,Richard J Ross
NEJM evidenceno. 2 (2023): EVIDoa2200182-EVIDoa2200182
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