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Neurotransmitter receptors mediate signal transduction at synaptic connections between neurons in the brain. We have been studying the molecular mechanisms in the regulation of neurotransmitter receptor function and synaptic transmission in the brain. We have recently focused on AMPA- and NMDA-type glutamate receptors, the major excitatory receptors in the central nervous system. We have examined the modulation of receptor function by protein phosphorylation and the regulation of the subcellular targeting of glutamate receptors to synapses. Studies in our laboratory have found that both AMPA and NMDA receptors are multiply phosphorylated by a variety of protein kinases. Phosphorylation regulates several functional properties of these receptors including ion channel properties and membrane targeting. We have also identified a variety of proteins that directly interact with glutamate receptors that are critical in the proper subcellular trafficking of these receptors and synaptic plasticity in the brain. These studies indicate that regulation of receptor function is a major mechanism for the regulation of synaptic transmission in the brain and is an important determinant of animal behavior. Importantly, recent evidence has implicated the regulation of glutamate receptor function in several neurological and psychiatric disorders including Alzheimer’s and Parkinson’s disease, ALS, schizophrenia, autism, mental retardation as well as in chronic pain and drug addiction.
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bioRxiv : the preprint server for biology (2024)
biorxiv(2024)
Yoichi Araki, Kacey E Rajkovich,Elizabeth E Gerber, Timothy R Gamache,Richard C Johnson, Thanh Hai N Tran,Bian Liu,Qianwen Zhu,Ingie Hong,Alfredo Kirkwood,Richard Huganir
Science (New York, N.Y.)no. 6686 (2024): eadk1291-eadk1291
Ingie Hong,Juhyun Kim,Thomas Hainmueller,Dong Won Kim,Richard C. Johnson,Soo Hyun Park,Nathachit Limjunyawong,Zhuonan Yang, David Cheon, Taeyoung Hwang,Amit Agarwal,Thibault Cholvin,
biorxiv(2023)
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medRxiv : the preprint server for health sciences (2023)
bioRxiv : the preprint server for biology (2023)
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bioRxiv : the preprint server for biology (2023)
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